多聚磷酸促进的酰胺羟醛缩合高效合成肉桂酰胺

Wang Enhua, Yang Lishou, He Lanfeng, Yang Qian, Wang Xue, Liu Yunlu, Li Manxiang, Lei Yang, Yang Xiaosheng

Department of Food and Medicine, Guizhou Vocational College of Agriculture, Qingzhen 551400, China.

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.

Molecules. 2024 Sep 29;29(19):4632. doi: 10.3390/molecules29194632.

Cinnamides are common core structures that exist in a great number of pharmaceuticals and natural products. The development of efficient methods for preparing cinnamides is in great need. We report herein an efficient polyphosphoric acid (PPA)-promoted direct aldol condensation of an amide for the convenient and straightforward preparation of cinnamides. A variety of cinnamides were obtained in moderate-to-excellent yields (65-89%). This strategy features the use of equivalent amides and a short reaction time.

肉桂酰胺是存在于大量药物和天然产物中的常见核心结构。迫切需要开发高效的制备肉桂酰胺的方法。我们在此报告一种高效的多磷酸（PPA）促进的酰胺直接羟醛缩合反应，用于方便、直接地制备肉桂酰胺。以中等到优异的产率（65 - 89%）获得了多种肉桂酰胺。该策略的特点是使用等当量的酰胺且反应时间短。