三株具有抗菌活性的新贝壳杉烷二萜类化合物。
Three New -Kaurane Diterpenes with Antibacterial Activity from .
机构信息
Yunnan Characteristic Plant Extraction Laboratory, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
出版信息
Molecules. 2024 Sep 29;29(19):4631. doi: 10.3390/molecules29194631.
Three novel -kaurane diterpenes, namely sigesbeckin A-C (-), in conjunction with eight previously identified analogues (-), were isolated from . Their chemical structures were resolved through multiple spectroscopic analyses. All compounds were assessed for antimicrobial bioactivity against methicillin-resistant (MRSA) and vancomycin-resistant (VRE) strains. In particular, compounds and demonstrated moderate efficacy, with MIC values of 64 μg/mL. Moreover, compounds , , and were found to synergize with doxorubicin hydrochloride (DOX) and vancomycin (VAN) against MRSA and VRE. The aforementioned findings offer valuable insights for the development of novel alternatives to antibiotics, which can effectively tackle the escalating issue of antibiotic resistance.
从 中分离得到了三种新型的贝壳杉烷二萜，分别为 sigesbeckin A-C（-），同时还分离得到了另外八种以前鉴定出的类似物（-）。通过多种光谱分析确定了它们的化学结构。所有化合物都进行了抗耐甲氧西林金黄色葡萄球菌（MRSA）和耐万古霉素肠球菌（VRE）的抗菌活性评估。特别是化合物 和 表现出中等的功效，MIC 值为 64 μg/mL。此外，化合物 、 、 和盐酸多柔比星（DOX）和万古霉素（VAN）对 MRSA 和 VRE 具有协同作用。上述发现为开发新型抗生素替代品提供了有价值的见解，这些替代品可以有效地解决抗生素耐药性日益严重的问题。
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