Heo Chang-Su, Kang Jong Soon, Yang Jeong-Wook, Lee Min Ah, Lee Hwa-Sun, Kim Chang Hwan, Shin Hee Jae
Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, 385 Haeyang-ro, Busan 49111, Republic of Korea.
Department of Marine Technology and Convergence Engineering, University of Science and Technology (UST), 217 Gajungro, Daejeon 34113, Republic of Korea.
Mar Drugs. 2025 Feb 10;23(2):78. doi: 10.3390/md23020078.
Four new kaurane-type diterpenoids, geliboluols A-D (-), along with one known analog (), were isolated from the culture broth of the marine-derived rare actinomycete . The structures of compounds - were determined by spectroscopic analysis (HR-ESIMS, 1D, and 2D NMR), the MPA method, and by comparing their optical rotation values with those in the literature. The new compounds were evaluated for their cytotoxicity against seven blood cancer cell lines by a CellTiter-Glo (CTG) assay and six solid cancer cell lines by a sulforhodamine B (SRB) assay. Among the new compounds, compound exhibited moderate cytotoxic activity against some blood cancer cell lines, with GI values ranging from 2.59 to 19.64 µM, and against solid cancer cell lines with GI values ranging from 4.34 to 7.23 µM.
从海洋来源的稀有放线菌的培养液中分离出四种新的贝壳杉烷型二萜类化合物，即吉贝波罗醇A - D（-），以及一种已知类似物（）。通过光谱分析（高分辨电喷雾电离质谱、一维和二维核磁共振）、MPA方法，并将它们的旋光值与文献中的值进行比较，确定了化合物 - 的结构。通过CellTiter - Glo（CTG）测定法评估了新化合物对七种血液癌细胞系的细胞毒性，并通过磺基罗丹明B（SRB）测定法评估了对六种实体癌细胞系的细胞毒性。在新化合物中，化合物 对一些血液癌细胞系表现出中等细胞毒性活性，GI值范围为2.59至19.64 μM，对实体癌细胞系的GI值范围为4.34至7.23 μM。
