A Machine Learning Model for Predicting the Propagation Rate Coefficient in Free-Radical Polymerization.

The propagation rate coefficient () is one of the most crucial kinetic parameters in free-radical polymerization (FRP) as it directly governs the rate of polymerization and the resulting molecular weight distribution. The in FRP can typically be obtained through experimental measurements or quantum chemical calculations, both of which can be time consuming and resource intensive. Herein, we developed a machine learning model based solely on the structural features of monomers involved in FRP, utilizing molecular embedding and a Lasso regression algorithm to predict more efficiently and accurately. The result shows that the model achieves a mean absolute percentage error (MAPE) of only 5.49% in the predictions for four new monomers, which indicates that the model exhibits strong generalization capabilities and provides reliable and robust predictions. In addition, this model can accurately predict the influence of the ester side chain length of (meth)acrylates on , aligning well with established scientific knowledge. This approach offers a straightforward and practical model for other researchers to rapidly obtain accurate values by employing monomer structural information. The model is sufficiently general to apply to a wide range of (meth)acrylate and butadiene FRP monomers, thereby supporting kinetic modeling of polymerization reactions.