Sato I, Tomita M, Ohe T, Haze K, Shimomura K
Chest. 1986 Jan;89(1):12-9. doi: 10.1378/chest.89.1.12.
From among 899 consecutive patients who underwent their first coronary arteriography, we selected 147 pts with vasospastic angina (VA) and 356 pts with classic angina (CA) and divided them into three different age groups: -49 years old, 50 to 59, and 60-. In these 899 pts, incidences of VA showed no increase with aging. Prevalence of coronary risk factors in CA, such as diabetes, hypercholesterolemia, hypertension, and obesity, was higher than in VA, although prevalence of smoking in CA was lower than in VA. In VA, we found an age-related increase in the incidence of smoking only, in contrast to the other four risk factors. The VA showed no age-related increase in the incidence of complication of fixed coronary stenosis. These findings suggest that aging and atherosclerosis might not play a major role in pathogenesis of VA, although the mere presence of atherosclerosis irrespective of its severity could interact with local susceptibility to spasm, leading to coronary vasospasm.
在899例连续接受首次冠状动脉造影的患者中，我们选取了147例血管痉挛性心绞痛（VA）患者和356例典型心绞痛（CA）患者，并将他们分为三个不同的年龄组：49岁及以下、50至59岁、60岁及以上。在这899例患者中，VA的发病率并未随年龄增长而增加。CA中冠状动脉危险因素如糖尿病、高胆固醇血症、高血压和肥胖的患病率高于VA，尽管CA中的吸烟患病率低于VA。在VA中，与其他四个危险因素相反，我们仅发现吸烟率随年龄增长而增加。VA中固定性冠状动脉狭窄并发症的发生率未显示出与年龄相关的增加。这些发现表明，衰老和动脉粥样硬化可能在VA的发病机制中不发挥主要作用，尽管无论严重程度如何，单纯存在动脉粥样硬化可能会与局部痉挛易感性相互作用，导致冠状动脉痉挛。
