Padure Adriana, Horhat Raluca, Talpos-Niculescu Ioana Cristina, Scheusan Roxana, Anghel Mirella D, Rusu Laura-Cristina, Lungeanu Diana
Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Clinic of Oro-Dental Diagnosis and Ergonomics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
J Clin Med. 2024 Sep 25;13(19):5723. doi: 10.3390/jcm13195723.
. Oral mucositis (OM) is a common adverse reaction associated with chemotherapy. We conducted a six-month longitudinal study to estimate the cumulative incidence of OM during the first six months of chemotherapy in adult patients with cancer other than head and neck cancer. Secondary objectives were as follows: (a) to scrutinize the oral health status of these patients and its evolution during chemotherapy, as assessed by oral health indices; (b) to estimate adherence to prescribed oral hygiene protocol during chemotherapy; and (c) to analyze ulceration-free survival in these patients. . Sixty-four patients participated. Dental health and oral hygiene were assessed at baseline and at the end. Every month, blood tests were performed and oral lesions were recorded. This study was observational, with the only intervention being instruction in the hygiene protocol. The cumulative incidence of OM was estimated with the patient as the unit of analysis. A repeated measures ANOVA was applied to analyze the monthly blood test results. Ulceration-free survival analysis was conducted with adherence to the oral hygiene protocol as a grouping factor, followed by Cox proportional-hazards regression. . The six-month cumulative incidence rate was 43.75%, 95%CI (31.58-56.67%) for OM grade 2 or higher. The hazard ratio of ulceration associated with adherence to the hygiene protocol was 0.154, 95%CI (0.049-0.483), adjusted for age, sex, baseline hygiene index, and class of treatment. Compliance with hygiene recommendations would decrease the OM risk by more than six times, compared to non-compliance.
口腔黏膜炎（OM）是化疗常见的不良反应。我们开展了一项为期六个月的纵向研究，以评估非头颈癌成年癌症患者化疗前六个月内OM的累积发病率。次要目标如下：（a）通过口腔健康指数评估这些患者的口腔健康状况及其在化疗期间的变化；（b）评估化疗期间对规定口腔卫生方案的依从性；（c）分析这些患者的无溃疡生存期。64名患者参与了研究。在基线期和结束时评估牙齿健康和口腔卫生状况。每月进行血液检查并记录口腔病变。本研究为观察性研究，唯一的干预措施是卫生方案指导。以患者为分析单位估计OM的累积发病率。应用重复测量方差分析来分析每月的血液检查结果。以对口腔卫生方案的依从性作为分组因素进行无溃疡生存期分析，随后进行Cox比例风险回归分析。2级及以上OM的六个月累积发病率为43.75%，95%CI（31.58 - 56.67%）。在对年龄、性别、基线卫生指数和治疗类别进行调整后，与遵守卫生方案相关的溃疡风险比为0.154，95%CI（0.049 - 0.483）。与不遵守相比，遵守卫生建议可使OM风险降低六倍以上。
