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分娩时催产素引产是发育性髋关节发育不良的危险因素吗?

Is Oxytocin Induction at Labor a Risk Factor for Developmental Hip Dysplasia?

作者信息

Emral Lütfiye İdil, Taşkın Ersin, Albayrak Aysun, Arslan Memnune, Soylu Demet

机构信息

Department of Pediatrics, Düziçi State Hospital, 80600 Osmaniye, Turkey.

Department of Orthopaedics and Traumatology, Düziçi State Hospital, 80600 Osmaniye, Turkey.

出版信息

J Clin Med. 2024 Sep 26;13(19):5724. doi: 10.3390/jcm13195724.

Abstract

Developmental hip dysplasia is a common condition with preventable causes, and its etiology is still not fully elucidated. In our study, we aimed to examine the use of synthetic oxytocin during childbirth as a potential risk factor for developmental hip dysplasia. This study involved comprehensive hip examinations on postnatal days 0, 14, 30, and 60, as well as hip ultrasonography results at 6-8 weeks. We specifically focused on healthy girls born with vaginal deliveries, comparing those who were applied with a low-dose oxytocin induction protocol (Group 2) and those who had vaginal deliveries without induction (Group 1). When the examination findings were compared with the hip ultrasonography findings (Type 2a was detected in the left hip of one patient (6.3%) in Group 1 and in the right hip of two patients (11.8%) in Group 2), it was seen that oxytocin induction did not cause a risk for developmental hip dysplasia. The oxytocin induction rate was higher in newborns weighing more than 3400 g ( = 0.04). A low-dose oxytocin protocol applied at birth has not been shown to harm the hip joint in the neonatal period and on ultrasonographic α and β angle measurements applied at 6-8 weeks. However, our study also highlights the need for new studies investigating oxytocin peripheral receptors and their effects, underscoring the importance of our findings in guiding future research in this area.

摘要

发育性髋关节发育不良是一种具有可预防病因的常见病症,其病因仍未完全阐明。在我们的研究中,我们旨在探讨分娩期间使用合成缩宫素作为发育性髋关节发育不良的潜在危险因素。这项研究包括在出生后第0、14、30和60天进行全面的髋关节检查,以及在6-8周时的髋关节超声检查结果。我们特别关注经阴道分娩的健康女孩,比较那些接受低剂量缩宫素引产方案的女孩(第2组)和那些未经引产经阴道分娩的女孩(第1组)。当将检查结果与髋关节超声检查结果进行比较时(第1组一名患者(6.3%)的左髋和第2组两名患者(11.8%)的右髋检测到2a型),发现缩宫素引产不会导致发育性髋关节发育不良的风险。体重超过3400g的新生儿缩宫素引产率更高(P = 0.04)。出生时应用的低剂量缩宫素方案在新生儿期以及在6-8周时进行的超声α和β角测量中未显示对髋关节有损害。然而,我们的研究也强调了需要开展新的研究来调查缩宫素外周受体及其作用,突出了我们的研究结果在指导该领域未来研究方面的重要性。

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