Farkas-Sütő Kristóf Attila, Grebur Kinga, Mester Balázs, Gyulánczi Flóra Klára, Bödör Csaba, Vágó Hajnalka, Merkely Béla, Szűcs Andrea
Heart and Vascular Center, Semmelweis University, Városmajor utca 68., 1122 Budapest, Hungary.
Department of Pathology and Experimental Cancer Research, Semmelweis University, Üllői út 26., 1085 Budapest, Hungary.
J Clin Med. 2024 Oct 3;13(19):5906. doi: 10.3390/jcm13195906.
: Although left ventricular excessive trabeculation (LVET) can cause heart failure, arrhythmia and thromboembolism, limited literature is available on the ECG characteristics of primary LVET with preserved left ventricular function (EF). We aimed to compare the ECG characteristics and cardiac MR (CMR) parameters of LVET individuals with preserved left ventricular EF to a control (C) group, to identify sex-specific differences, and to compare the genetic subgroups of LVET with each other and with a C population. : In our study, we selected 69 LVET individuals (EF > 50%) without any comorbidities and compared them to 69 sex- and age-matched control subjects (42% females in both groups, = 1.000; mean age LVET-vs-C: 38 ± 14 vs. 38 ± 14 years = 0.814). We analyzed the pattern and notable parameters of the 12-lead ECG recordings. We determined the volumetric and functional parameters, as well as the muscle mass values of the left and right ventricles (LV, RV) based on the CMR recordings. Based on the genotype, three subgroups were established: pathogenic, variant of uncertain significance and benign. : In the LVET group, we found normal but elevated volumetric and muscle mass values and a decreased LV_EF, wider QRS, prolonged QTc, higher RV Sokolow index values and lower T wave amplitude compared to the C. When comparing MR and ECG parameters between genetic subgroups, only the QTc showed a significant difference. Over one-third of the LVET population had arrhythmic episodes and a positive family history. : The subclinical morphological and ECG changes and the clinical background of the LVET group indicate the need for follow-up of this population, even with preserved EF.
尽管左心室过度小梁化（LVET）可导致心力衰竭、心律失常和血栓栓塞，但关于左心室功能（EF）保留的原发性LVET的心电图特征的文献有限。我们旨在比较左心室EF保留的LVET个体与对照组（C组）的心电图特征和心脏磁共振（CMR）参数，以确定性别特异性差异，并比较LVET的遗传亚组之间以及与C人群的差异。：在我们的研究中，我们选择了69例无任何合并症的LVET个体（EF>50%），并将他们与69例性别和年龄匹配的对照受试者进行比较（两组女性均占42%，P = 1.000；LVET组与C组的平均年龄：38±14岁 vs. 38±14岁，P = 0.814）。我们分析了12导联心电图记录的模式和显著参数。我们根据CMR记录确定了左、右心室（LV、RV）的容积和功能参数以及肌肉质量值。根据基因型，建立了三个亚组：致病型、意义未明变异型和良性型。：在LVET组中，我们发现与C组相比，容积和肌肉质量值正常但升高，LV_EF降低，QRS增宽，QTc延长，右心室索科洛夫指数值更高，T波振幅更低。在比较遗传亚组之间的磁共振和心电图参数时，只有QTc显示出显著差异。超过三分之一的LVET人群有心律失常发作和阳性家族史。：LVET组的亚临床形态学和心电图变化以及临床背景表明，即使EF保留，也需要对该人群进行随访。
