Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
Department of Sports Medicine, Semmelweis University, Budapest, Hungary.
PLoS One. 2021 Oct 12;16(10):e0258362. doi: 10.1371/journal.pone.0258362. eCollection 2021.
The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventricular (LV) myocardial mass values, volumetric and functional parameters and the correspondence of these parameters using the TB method.
Healthy European adults (n = 200, age: 39.4 ± 12 years, males: 100) were examined with CMR and evaluated with a TB postprocessing method. They were stratified by sex and age (Group A: 18-29, Group B: 30-39, Group C: 40-49, Group D: >50 years). The calculated parameters were indexed to body surface area (i).
The normal reference ranges for the studied parameters were assessed in each age group. Significant biometric differences in LV parameters and mass-to-volume ratios were found between males and females, and the left ventricular compacted myocardial mass (LVCMi) and TPMi differences remained significant after stratification by age. Unlike other LV volumetric and functional parameters and mass-to-volume ratios, the TPMi, the LVCMi and the TPMi-to-LVCMi ratio did not differ among age groups in males or females. This finding was strengthened by the lack of correlation between TPMi and age.
Age- and sex-related normal reference ranges for LV volumetric and functional parameters and LVCMi and TPMi values were established using a TB postprocessing method. TPMi, LVCMi and their ratio did not change over time. The TPMi-to-LVCMi and the mass-to-volume ratios might have clinical utility in the differential diagnosis of conditions with LV hypertrabeculation.
基于阈值的（TB）小梁和乳头肌质量（TPM）定量方法用于心脏 MRI（CMR）计算的数值与传统轮廓技术不同。我们旨在确定左心室（LV）心肌质量值、容积和功能参数的性别和年龄相关的正常参考范围，并使用 TB 方法确定这些参数的对应关系。
健康的欧洲成年人（n = 200，年龄：39.4 ± 12 岁，男性：100）接受 CMR 检查，并使用 TB 后处理方法进行评估。他们按性别和年龄分层（A 组：18-29 岁，B 组：30-39 岁，C 组：40-49 岁，D 组：>50 岁）。计算的参数按体表面积（i）进行索引。
在每个年龄组中评估了所研究参数的正常参考范围。LV 参数和质量-体积比存在显著的性别差异，男性和女性之间存在显著差异，并且在按年龄分层后，LV 致密心肌质量（LVCMi）和 TPMi 差异仍然显著。与其他 LV 容积和功能参数以及质量-体积比不同，男性和女性中，TPMi、LVCMi 和 TPMi-to-LVCMi 比值在各年龄组之间没有差异。这种发现因 TPMi 与年龄之间缺乏相关性而得到加强。
使用 TB 后处理方法建立了 LV 容积和功能参数以及 LVCMi 和 TPMi 值的年龄和性别相关的正常参考范围。TPMi、LVCMi 及其比值不会随时间而变化。TPMi-to-LVCMi 和质量-体积比可能在 LV 心肌肥厚的鉴别诊断中具有临床应用价值。
