Rosehip Extract Decreases Reactive Oxygen Species Production and Lipid Accumulation in Hypertrophic 3T3-L1 Adipocytes with the Modulation of Inflammatory State.

BACKGROUND

L. (rosehip) is used worldwide in traditional medicine as a plant with medicinal properties. However, its anti-obesity effects are not fully explained on a transcriptional level.

METHODS

In the present work, the 3T3-L preadipocytes were utilized to explore the impact of fruit extract (RCE) on the cellular and molecular pathways involved in adipocyte hypertrophy.

RESULTS

Obtained results showed the ability of RCE to reduce lipid overloads in hypertrophic adipocytes associated with the down-regulation of mRNA expressions of adipogenic transcription factors such as , , and as well as genes involved in lipid biosyntheses such as , and . Moreover, obesity-associated oxidative stress (antioxidant enzyme activities and ROS generation) and inflammation were ameliorated in RCE-treated hypertrophic adipocytes. The mRNA and protein levels of adipokines such as leptin, resistin, and adiponectin were restored to more favorable levels.

CONCLUSIONS

fruit might be a valuable source of phytochemicals in preventing obesity and obesity-related metabolic complications.