Department of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego St., 60-627 Poznan, Poland.
Nutrients. 2024 Sep 27;16(19):3269. doi: 10.3390/nu16193269.
L. (rosehip) is used worldwide in traditional medicine as a plant with medicinal properties. However, its anti-obesity effects are not fully explained on a transcriptional level.
In the present work, the 3T3-L preadipocytes were utilized to explore the impact of fruit extract (RCE) on the cellular and molecular pathways involved in adipocyte hypertrophy.
Obtained results showed the ability of RCE to reduce lipid overloads in hypertrophic adipocytes associated with the down-regulation of mRNA expressions of adipogenic transcription factors such as , , and as well as genes involved in lipid biosyntheses such as , and . Moreover, obesity-associated oxidative stress (antioxidant enzyme activities and ROS generation) and inflammation were ameliorated in RCE-treated hypertrophic adipocytes. The mRNA and protein levels of adipokines such as leptin, resistin, and adiponectin were restored to more favorable levels.
fruit might be a valuable source of phytochemicals in preventing obesity and obesity-related metabolic complications.
在传统医学中，L.（玫瑰果）作为一种具有药用特性的植物，在全球范围内被使用。然而，其在转录水平上的抗肥胖效果尚未得到充分解释。
本研究工作利用 3T3-L1 前脂肪细胞，探讨了果实提取物（RCE）对脂肪细胞肥大过程中涉及的细胞和分子途径的影响。
研究结果表明，RCE 能够减少肥大脂肪细胞中的脂质过载，下调脂肪生成转录因子如、、和脂质生物合成相关基因如、和的 mRNA 表达。此外，RCE 处理的肥大脂肪细胞中的肥胖相关氧化应激（抗氧化酶活性和 ROS 生成）和炎症得到改善。脂肪细胞因子（瘦素、抵抗素和脂联素）的 mRNA 和蛋白水平恢复到更有利的水平。
玫瑰果可能是预防肥胖和肥胖相关代谢并发症的有价值的植物化学物质来源。
