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地中海饮食依从性对慢性心力衰竭患者失代偿的影响。

The Influence of Adherence to a Mediterranean Diet on Decompensation in Patients with Chronic Heart Failure.

机构信息

Department of Internal Medicine, University Hospital Virgen del Rocío, 41013 Seville, Spain.

出版信息

Nutrients. 2024 Sep 27;16(19):3278. doi: 10.3390/nu16193278.

Abstract

BACKGROUND

Chronic heart failure (CHF) is a major health problem, representing the main cause of hospitalization in people over 65 years of age. Several studies have associated the Mediterranean diet with a cardioprotective function, improving prognoses in patients with high cardiovascular risk. Our main objective is to determine whether higher adherence to the Mediterranean diet is associated with a lower severity of CHF, based on the number of decompensations and disease complications.

METHODS

This study was a single-center retrospective cohort study conducted at the Virgen del Rocío Hospital (Seville). Adherence to a Mediterranean diet was determined by the Mediterranean Diet Adherence Screener (MEDAS) in patients with chronic heart failure in a state of clinical stability, the number of decompensations in the 12 months before inclusion, cardiac biomarkers (NT-proBNP and CA125), evaluation of dyspnea, and quality of life assessment according to NYHA and KCCQ scales and analytical profiles.

RESULTS

Seventy-two patients were included (35 with high adherence to the Mediterranean diet and 37 with low adherence). The mean age was 81.29 ± 0.86 years. A trend towards fewer decompensations (1.49 ± 0.14 vs. 1.92 ± 0.17, = 0.054) and lower NT-proBNP values (2897.02 ± 617.16 vs. 5227.96 ± 1047.12; = 0.088) was observed in patients with high adherence compared to those with low adherence to the Mediterranean diet.

CONCLUSIONS

Our results suggest that patients with CHF and high adherence to the Mediterranean diet have a tendency towards an improved cardiac profile, indicated by fewer decompensations and lower NT-proBNP levels. Future clinical trials are needed to substantiate these hypotheses.

摘要

背景

慢性心力衰竭(CHF)是一个主要的健康问题,是 65 岁以上人群住院的主要原因。多项研究表明,地中海饮食与心脏保护功能有关,可以改善心血管高危患者的预后。我们的主要目的是确定较高的地中海饮食依从性是否与心力衰竭严重程度降低相关,其依据是心力衰竭失代偿和疾病并发症的数量。

方法

这是一项在塞维利亚的 Virgen del Rocío 医院进行的单中心回顾性队列研究。在临床稳定的慢性心力衰竭患者中,通过地中海饮食依从性筛查器(MEDAS)确定地中海饮食的依从性,在纳入前 12 个月内的心力衰竭失代偿次数,心脏生物标志物(NT-proBNP 和 CA125),呼吸困难评估和生活质量评估,根据 NYHA 和 KCCQ 量表和分析指标进行评估。

结果

共纳入 72 例患者(高地中海饮食依从组 35 例,低地中海饮食依从组 37 例)。平均年龄为 81.29 ± 0.86 岁。与低地中海饮食依从组相比,高地中海饮食依从组的心力衰竭失代偿次数(1.49 ± 0.14 次 vs. 1.92 ± 0.17 次, = 0.054)和 NT-proBNP 值(2897.02 ± 617.16 pg/ml vs. 5227.96 ± 1047.12 pg/ml; = 0.088)有降低趋势。

结论

我们的结果表明,与低地中海饮食依从组相比,CHF 患者且地中海饮食依从性较高的患者心脏状况有改善趋势,表现为心力衰竭失代偿次数减少和 NT-proBNP 水平降低。需要进一步的临床试验来证实这些假设。

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