Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China.
Nutrients. 2024 Sep 30;16(19):3312. doi: 10.3390/nu16193312.
: The causal association of specific gut microbiota with dementia remains incompletely understood. We aimed to access the causal relationships in which one or more gut microbiota account for dementia. : Using data from the MiBioGen and FinnGen consortia, we employed multiple Mendelian randomization (MR) approaches including two-sample MR (TSMR), multivariable MR (MVMR), and Bayesian model averaging MR to comprehensively evaluate the causal associations between 119 genera and dementia, and to prioritize the predominant bacterium. : We identified 21 genera that had causal effects on dementia and suggested (OR = 0.827, 95%CI = 0.722-0.948, marginal inclusion probability [MIP] = 0.464; model-averaged causal estimate [MACE] = -0.068) and (OR = 0.770, 95%CI = 0.693-0.855, MIP = 0.898, MACE = -0.204) as the predominant genera for AD and all-cause dementia. : These findings confirm the causal relationships between specific gut microbiota and dementia, highlighting the necessity of multiple MR approaches in gut microbiota analysis, and provides promising genera as potential novel biomarkers for dementia risk.
肠道微生物群与痴呆的因果关联尚不完全清楚。本研究旨在确定一个或多个肠道微生物群与痴呆之间的因果关系。
使用 MiBioGen 和 FinnGen 联盟的数据，我们采用了多种孟德尔随机化（MR）方法，包括两样本 MR（TSMR）、多变量 MR（MVMR）和贝叶斯模型平均 MR，以综合评估 119 个属与痴呆之间的因果关联，并确定主要细菌。
我们确定了 21 个对痴呆有因果影响的属，并提出 （OR = 0.827，95%CI = 0.722-0.948，边际纳入概率 [MIP] = 0.464；模型平均因果估计值 [MACE] = -0.068）和 （OR = 0.770，95%CI = 0.693-0.855，MIP = 0.898，MACE = -0.204）是 AD 和全因痴呆的主要细菌。
这些发现证实了特定肠道微生物群与痴呆之间的因果关系，强调了在肠道微生物群分析中采用多种 MR 方法的必要性，并提供了有希望的细菌作为痴呆风险的潜在新型生物标志物。
