《内科住院老年患者遵循地中海饮食与氧化应激和炎症生物标志物的关系》

Adherence to Mediterranean Diet and Biomarkers of Redox Balance and Inflammation in Old Patients Hospitalized in Internal Medicine.

机构信息

Department of Medical and Surgical Sciences, University of Foggia, Viale Pinto 1, 71122 Foggia, Italy.

Department of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 41-808 Katowice, Poland.

出版信息

Nutrients. 2024 Oct 2;16(19):3359. doi: 10.3390/nu16193359.

DOI:10.3390/nu16193359

PMID:39408326

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11478664/

Abstract

BACKGROUND/OBJECTIVES: We have previously described that low adherence to the Mediterranean diet (MD) in elderly patients admitted in internal medicine wards is linked to poorer clinical outcomes. This investigation was designed to explore whether adherence to the MD is related to circulating markers of redox balance and inflammation in this clinical scenario.

METHODS

A cross-sectional study was performed on 306 acute old patients hospitalized in internal medicine wards. Adherence to the MD was estimated by the Italian Mediterranean Index (IMI). The circulating markers of redox balance were assessed in serum and erythrocytes and correlated with inflammatory markers across different MD adherence groups.

RESULTS

Compared to the patients with high adherence, those with low adherence to the MD exhibited severely impaired redox balance, as evidenced by a higher GSSG/GSH ratio and increased serum hydroxynonenal/malondialdehyde-protein adducts. No modifications were described in the expression of antioxidant enzymes in peripheral blood mononuclear cells. Patients with low adherence to the MD exhibited a higher neutrophil-to-lymphocyte ratio and markers of systemic inflammation, as well as raised levels of interleukin-6 and tumor necrosis factor, compared to those with high MD adherence. A strong association was observed between the circulating markers of redox balance and inflammation/immune response, with the highest regression coefficients found in the low adherence group.

CONCLUSIONS

Old patients admitted to internal medicine wards with low adherence to the MD display unfavorable profiles of the circulating markers of redox balance and inflammation. It is conceivable that such effects on redox balance can be linked to the high polyphenol content of MD. This study supports the rationale for intervention trials that attest to the effectiveness of MD as a nutritional strategy for disease prevention.

摘要

背景/目的：我们之前曾描述过，内科病房中老年人对地中海饮食（Mediterranean diet，MD）的低依从性与较差的临床结局有关。本研究旨在探讨在这种临床情况下，MD 的依从性是否与氧化还原平衡和炎症的循环标志物有关。

方法

对 306 名在内科病房住院的急性老年患者进行了横断面研究。采用意大利地中海指数（Italian Mediterranean Index，IMI）评估 MD 的依从性。在血清和红细胞中评估氧化还原平衡的循环标志物，并在不同 MD 依从性组中与炎症标志物相关。

结果

与高依从性患者相比，MD 低依从性患者的氧化还原平衡严重受损，表现为 GSSG/GSH 比值升高和血清羟壬烯醛/丙二醛-蛋白质加合物增加。外周血单个核细胞中抗氧化酶的表达没有改变。与高 MD 依从性患者相比，MD 低依从性患者的中性粒细胞与淋巴细胞比值和全身炎症标志物升高，以及白细胞介素-6 和肿瘤坏死因子水平升高。氧化还原平衡的循环标志物与炎症/免疫反应之间存在很强的相关性，在低依从性组中发现了最高的回归系数。