Kietzmann H, Schwarze I, Grote W, Ravens U, Jänig U, Harms D
Dtsch Med Wochenschr. 1986 Jan 10;111(2):60-2. doi: 10.1055/s-2008-1068402.
A 22-year-old woman suffering from dyskeratosis follicularis Darier became pregnant 4 months after the last dose of etretinate (Tigason). The pregnancy was terminated in the 10th week because of teratogenic risk. The pathological examination of the fetus revealed severe malformation of the left leg with aplasia of tibia and fibula, as well as hypoplasia of the left femur. This observation emphasises the necessity of effective contraception even after discontinuation of etretinate therapy.
一名患有毛囊角化病（达里埃病）的22岁女性在最后一剂阿维A酯（银屑灵）服用4个月后怀孕。由于存在致畸风险，妊娠在第10周时终止。对胎儿的病理检查显示左腿严重畸形，胫骨和腓骨发育不全，以及左股骨发育不良。这一观察结果强调了即使在阿维A酯治疗停药后仍需采取有效避孕措施的必要性。
