Antibacterial Activity and Mechanism of (DC.) Danser and Its Active Ingredients.

(DC.) Danser is a traditional Chinese herbal medicine. It has not been reported regarding antibacterial active ingredients and mechanisms of action. However, the Chinese patent medicine Yinhua Miyanling Tablets containing has an obvious anti-infective effect in our patent. Therefore, we speculate that may have antibacterial activity. The purpose of this paper is to study the antibacterial effect and mechanism of and find active compounds with antibacterial activity and a mechanism. We studied the antibacterial effect and mechanism of extract. The compounds in the ethyl acetate extract of were preliminarily identified by UPLC-Q-Orbitrap and analyzed by mass spectrometry. Above all, the antibacterial effect and antibacterial mechanism of the active components of were determined. Finally, we found, for the first time, that has a good antibacterial effect and ethyl acetate extract has the best effect. In addition, we found, for the first time, that it has an active component, 4-indolecarbaldehyde, and the component has a good broad-spectrum antibacterial effect. Above all, the active chemical 4-indolecarbaldehyde of can destroy the bacterial structure, make it unable to maintain normal morphology, and significantly increase the number of deaths. In short, has an antibacterial effect, and one of its main antibacterial components is 4-indolecarbaldehyde. The antibacterial mechanism of and 4-indolecarbaldehyde is related to the change in bacterial membrane permeability.