Sacquegna T, D'Addato M, Baldrati A, Cortelli P, Lamieri C, Merlo Pich E, Vitacchiano G, Pedrini L
Eur Neurol. 1986;25(1):36-9. doi: 10.1159/000115984.
This study analyzed 76 consecutive patients with carotid transient ischemic attacks (TIA) and carotid lesions appropriate to symptoms who underwent endarterectomy during the period 1975-1981. The mean age of the patients was 51.9 +/- 8 years at the time of surgery. Hypertension was present in 32.9%, diabetes mellitus in 13%, ischemic cardiopathy in 8.2% and peripheral vascular disease in 6.6%. Operative mortality was 1.3% and harder morbidity 4%. The average follow-up was 2.6 years (range 1-7 years). The observed 5-year survival rate was 85.2% compared to the expected rate of 92.4% in a normal population. During the follow-up 5 patients had a stroke: the cumulative stroke rate was 4.6% at 1 year and 7.9% at 3 years. 18 patients had further TIAs (13 carotid TIAs and 5 vertebro-basilar TIAs). 6 patients suffered myocardial infarction. The prognosis of TIA patients treated with endarterectomy is difficult to evaluate because the natural history of TIAs is still undefined.
本研究分析了1975年至1981年期间连续76例患有颈动脉短暂性脑缺血发作（TIA）且颈动脉病变与症状相符并接受了内膜切除术的患者。手术时患者的平均年龄为51.9±8岁。32.9%的患者患有高血压，13%患有糖尿病，8.2%患有缺血性心脏病，6.6%患有周围血管疾病。手术死亡率为1.3%，严重并发症发生率为4%。平均随访时间为2.6年（范围1至7年）。观察到的5年生存率为85.2%，而正常人群的预期生存率为92.4%。随访期间，5例患者发生了中风：1年时累积中风率为4.6%，3年时为7.9%。18例患者出现了进一步的短暂性脑缺血发作（13例颈动脉短暂性脑缺血发作和5例椎基底动脉短暂性脑缺血发作）。6例患者发生了心肌梗死。由于短暂性脑缺血发作的自然病史仍不明确，因此很难评估接受内膜切除术治疗的短暂性脑缺血发作患者的预后。
