Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Lodz, 1 Muszyńskiego St., 90-151 Lodz, Poland.
Int J Mol Sci. 2024 Sep 25;25(19):10323. doi: 10.3390/ijms251910323.
Juglanin (kaempferol 3--α-L-arabinofuranoside) is a flavonol glycoside occurring in many plants, including its commercial sources , and . Recent extensive studies have explored the potential of using juglanin in various pathological conditions, including cardiovascular disorders, central nervous and skeletal system disorders, metabolic syndrome, hepatic injury, and cancers. The results indicated a wide range of effects, like anti-inflammatory, anti-oxidant, anti-fibrotic, anti-thrombotic, anti-angiogenic, hepatoprotective, hypolipidemic, hypoglycemic, anti-apoptotic (normal cells), and pro-apoptotic (cancer cells). The health-promoting properties of juglanin can be attributed to its influence on many signaling pathways, associated with SIRT1, AMPK, Nrf2, STING, TLR4, MAPKs, NF-κB, AKT, JAK, and their downstream genes. This review primarily summarizes the current knowledge of molecular mechanisms, pharmacokinetics, biocompatibility, and human use safety of juglanin. In addition, the most promising new plant sources and other existing challenges and prospects have also been reviewed and discussed, aiming to provide direction and rationale for the further development and broader pharmaceutical application of juglanin.
京尼平苷（山奈酚 3--α-L-阿拉伯呋喃糖苷）是一种黄酮醇糖苷，存在于许多植物中，包括其商业来源 和 。最近的广泛研究探索了京尼平苷在各种病理条件下的潜在用途，包括心血管疾病、中枢和骨骼系统疾病、代谢综合征、肝损伤和癌症。结果表明，它具有广泛的作用，如抗炎、抗氧化、抗纤维化、抗血栓形成、抗血管生成、保肝、降血脂、降血糖、抗细胞凋亡（正常细胞）和促细胞凋亡（癌细胞）。京尼平苷的促进健康特性可归因于其对与 SIRT1、AMPK、Nrf2、STING、TLR4、MAPKs、NF-κB、AKT、JAK 及其下游基因相关的许多信号通路的影响。本综述主要总结了京尼平苷的分子机制、药代动力学、生物相容性和人体使用安全性的最新知识。此外，还对最有前途的新植物来源和其他现有挑战和前景进行了综述和讨论，旨在为京尼平苷的进一步开发和更广泛的药物应用提供方向和依据。
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