Dabravolski Siarhei A, Sukhorukov Vasily N, Kalmykov Vladislav A, Grechko Andrey V, Shakhpazyan Nikolay K, Orekhov Alexander N
Department of Clinical Diagnostics, Vitebsk State Academy of Veterinary Medicine [UO VGAVM], 7/11 Dovatora Str., 210026 Vitebsk, Belarus.
Laboratory of Cellular and Molecular Pathology of Cardiovascular System, AP Avtsyn Research Institute of Human Morphology, 3 Tsyurupy Str., 117418 Moscow, Russia.
Biomedicines. 2022 Jan 24;10(2):254. doi: 10.3390/biomedicines10020254.
Kruppel like factor 2 (KLF2) is a mechanosensitive transcription factor participating in the regulation of vascular endothelial cells metabolism. Activating KLF2 in endothelial cells induces eNOS (endothelial nitric oxide synthase) expression, subsequent NO (nitric oxide) release, and vasodilatory effect. In addition, many KLF2-regulated genes participate in the anti-thrombotic, antioxidant, and anti-inflammatory activities, thereby preventing atherosclerosis development and progression. In this review, we summarise recent evidence suggesting that KLF2 plays a major role in regulating atheroprotective effects in endothelial cells. We also discuss several recently identified repurposed drugs and natural plant-based bioactive compounds with KLF2-mediated atheroprotective activities. Herein, we present a comprehensive overview of the role of KLF2 in atherosclerosis and as a pharmacological target for different drugs and natural compounds and highlight the potential application of these phytochemicals for the treatment of atherosclerosis.
Kruppel样因子2（KLF2）是一种机械敏感性转录因子，参与血管内皮细胞代谢的调节。在内皮细胞中激活KLF2可诱导内皮型一氧化氮合酶（eNOS）表达、随后释放一氧化氮（NO）并产生血管舒张作用。此外，许多受KLF2调控的基因参与抗血栓形成、抗氧化和抗炎活动，从而预防动脉粥样硬化的发生和发展。在本综述中，我们总结了最近的证据，表明KLF2在调节内皮细胞的抗动脉粥样硬化作用中起主要作用。我们还讨论了几种最近确定的具有KLF2介导的抗动脉粥样硬化活性的重新利用药物和天然植物来源的生物活性化合物。在此，我们全面概述了KLF2在动脉粥样硬化中的作用以及作为不同药物和天然化合物的药理学靶点，并强调了这些植物化学物质在治疗动脉粥样硬化方面的潜在应用。
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