National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2024 Sep 27;25(19):10392. doi: 10.3390/ijms251910392.
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive loss of motor neurons, with limited effective treatments. Recently, the exploration of natural products has unveiled their potential in exerting neuroprotective effects, offering a promising avenue for ALS therapy. In this study, the therapeutic effects of rutin, a natural flavonoid glycoside with neuroprotective properties, were evaluated in a superoxide dismutase 1 (SOD1)-G93A mouse model of ALS. We showed that rutin reduced the level of SOD1 aggregation and diminished glial cell activation in spinal cords and brainstems, resulting in significantly improved motor function and motor neuron restoration in SOD1-G93A mice. Our findings indicated that rutin's multi-targeted approach to SOD1-related pathology makes it a promising candidate for the treatment of ALS.
肌萎缩侧索硬化症（ALS）是一种神经退行性疾病，其特征是运动神经元进行性丧失，目前治疗方法有限。最近，对天然产物的探索揭示了它们在发挥神经保护作用方面的潜力，为 ALS 的治疗提供了一个有前途的途径。在这项研究中，评估了具有神经保护特性的天然类黄酮糖苷芦丁在肌萎缩侧索硬化症 SOD1-G93A 小鼠模型中的治疗效果。我们发现芦丁降低了 SOD1 聚集的水平，并减少了脊髓和脑干中的神经胶质细胞激活，从而显著改善了 SOD1-G93A 小鼠的运动功能和运动神经元恢复。我们的研究结果表明，芦丁针对 SOD1 相关病理的多靶点作用使其成为治疗 ALS 的有前途的候选药物。
