Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.
Klaipeda University Hospital, Lithuanian University of Health Sciences, 44307 Kaunas, Lithuania.
Int J Mol Sci. 2024 Sep 29;25(19):10502. doi: 10.3390/ijms251910502.
Permanent inflammatory demyelinating and neurodegenerative processes lead to neurological disability in patients with multiple sclerosis (MS). The anti-inflammatory properties of vitamin D (VitD) are well established, but its role in neurodegeneration is still uncertain. The usefulness of the serum concentration of VitD as a potential biomarker in evaluating brain injury in terms of recently known smoldering MS was under consideration. Methods: We assessed the concentrations of the parameters of brain injury (NF-H, GPAF, S100B, UCHL1) in the cerebrospinal fluid (CSF) of relapsing-remitting (RRMS, = 123) and progressive MS (PMS, = 88) patients in the group with normal levels of VitD (VitDn) and in the VitD deficiency group (VitDd). The levels of NF-H and UCHL1 were higher in the group of VitDd compared to VitDn. The higher serum levels of VitD were correlated with lower concentrations of GFAP, NF-H and S100B in the CSF of the whole group of MS patients and in women with MS as opposed to the levels of UCHL1. In men, there were noted negative correlations between the levels of serum VitD and GFAP and NF-H in CSF but not between VitD and S100B and UCHL1. The negative correlations were observed between VitD and the selected parameters of brain injury in MS patients, in women as well as in men. The concentrations of serum VitD together with selected parameters of brain injury in CSF seem to be promising biomarkers of neurodegeneration processes in smoldering MS.
持续性炎症性脱髓鞘和神经退行性过程导致多发性硬化症（MS）患者出现神经功能障碍。维生素 D（VitD）的抗炎特性已得到充分证实，但它在神经退行性变中的作用仍不确定。考虑到最近已知的潜伏性 MS，我们正在研究血清 VitD 浓度作为评估脑损伤的潜在生物标志物的有用性。方法：我们评估了复发缓解型 MS（RRMS，n=123）和进展型 MS（PMS，n=88）患者 VitD 正常组（VitDn）和 VitD 缺乏组（VitDd）脑脊液中脑损伤参数（NF-H、GPAF、S100B、UCHL1）的浓度。与 VitDn 相比，VitDd 组 NF-H 和 UCHL1 水平更高。在整个 MS 患者组和 MS 女性患者中，VitD 血清水平较高与 CSF 中 GFAP、NF-H 和 S100B 浓度降低相关，而与 UCHL1 水平无关。在男性中，血清 VitD 水平与 CSF 中 GFAP 和 NF-H 之间存在负相关，但 VitD 与 S100B 和 UCHL1 之间不存在负相关。VitD 与 MS 患者、女性和男性的选定脑损伤参数之间存在负相关。血清 VitD 浓度与 CSF 中选定的脑损伤参数似乎是潜伏性 MS 中神经退行性过程的有前途的生物标志物。
