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多糖对孢子叶提取物的抗黑色素生成作用。

Anti-Melanogenic Effects of a Polysaccharide Isolated from Sporophyll Extracts.

机构信息

Food Processing Research Group, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.

Department of Food Science & Biotechnology, Sejong University, Seoul 05006, Republic of Korea.

出版信息

Int J Mol Sci. 2024 Oct 2;25(19):10624. doi: 10.3390/ijms251910624.

DOI:10.3390/ijms251910624
PMID:39408953
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476543/
Abstract

is a temperate brown alga known to exert free radical-scavenging and anti-inflammatory effects. In this study, we investigated the skin-whitening effects of sporophyll extracts (UPEs) in α-melanocyte-stimulating hormone (α-MSH)-stimulated B16F10 melanoma cells. The crude polysaccharide fraction (UPF) was obtained via ethanol precipitation. Four polysaccharide fractions (UPF1-4) were isolated and purified using ion-exchange column chromatography, and their anti-melanogenic activity was evaluated. UPF3 exhibited the highest anti-melanogenic activity, showing the highest sulfate (39.79%), fucose (143 μg/mg), and galactose (208 μg/mg) contents. UPF3 significantly inhibited intracellular tyrosinase activity in B16F10 cells. We also evaluated the melanogenic signaling pathway to determine the mechanism of action of UPF3 in melanongenesis. UPF3 reduced the expression of tyrosinase-related protein-1 (TRP-1), tyrosinase-related protein-2 (TRP-2), and tyrosinase, which play important roles in melanin production. Therefore, UPF3 has high potential for use in skin-whitening functional pharmaceuticals and cosmetics.

摘要

是一种温带褐色海藻，已知具有清除自由基和抗炎作用。在这项研究中，我们研究了孢子叶提取物（UPEs）在α-黑色素细胞刺激激素（α-MSH）刺激的 B16F10 黑色素瘤细胞中的美白作用。通过乙醇沉淀获得粗多糖级分（UPF）。使用离子交换柱层析分离和纯化了四个多糖级分（UPF1-4），并评估了它们的抗黑色素生成活性。UPF3 表现出最高的抗黑色素生成活性，硫酸根（39.79%）、岩藻糖（143μg/mg）和半乳糖（208μg/mg）含量最高。UPF3 显著抑制了 B16F10 细胞内的酪氨酸酶活性。我们还评估了黑色素生成信号通路，以确定 UPF3 在黑色素生成中的作用机制。UPF3 降低了在黑色素生成中起重要作用的酪氨酸酶相关蛋白-1（TRP-1）、酪氨酸酶相关蛋白-2（TRP-2）和酪氨酸酶的表达。因此，UPF3 具有在皮肤美白功能性药物和化妆品中应用的巨大潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/32f980a5f8e2/ijms-25-10624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/d6a5efd238fd/ijms-25-10624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/966549d89957/ijms-25-10624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/03d5574532b7/ijms-25-10624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/32f980a5f8e2/ijms-25-10624-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/d6a5efd238fd/ijms-25-10624-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/966549d89957/ijms-25-10624-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/03d5574532b7/ijms-25-10624-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f07c/11476543/32f980a5f8e2/ijms-25-10624-g004.jpg

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