• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

固体脂质纳米粒：三阴性乳腺癌治疗的一种选择。

Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer.

机构信息

Laboratorio de Física Médica, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.

Laboratorio de Fármaco-Oncología y Nanomedicina, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Mexico City 14080, Mexico.

出版信息

Int J Mol Sci. 2024 Oct 5;25(19):10712. doi: 10.3390/ijms251910712.

DOI:10.3390/ijms251910712
PMID:39409041
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11476567/
Abstract

Within the field of nanomedicine, which is revolutionizing cancer treatment, solid lipid nanoparticles (SLNs) have shown advantages over conventional chemotherapy when tested on cancer cells in preclinical studies. SLNs have proven to be an innovative strategy for the treatment of triple-negative breast cancer cells, providing greater efficiency than existing treatments in various studies. The encapsulation of antineoplastic drugs in SLNs has facilitated a sustained, controlled, and targeted release, which enhances therapeutic efficiency and reduces adverse effects. Moreover, the surface of SLNs can be modified to increase efficiency. For instance, the coating of these particles with polyethylene glycol (PEG) decreases their opsonization, resulting in a longer life in the circulatory system. The creation of positively charged cationic SLNs (cSLNs), achieved by the utilization of surfactants or ionic lipids with positively charged structural groups, increases their affinity for cell membranes and plasma proteins. Hyaluronic acid has been added to SLNs so that the distinct pH of tumor cells would stimulate the release of the drug and/or genetic material. The current review summarizes the recent research on SLNs, focusing on the encapsulation and transport of therapeutic agents with a cytotoxic effect on triple-negative breast cancer.

摘要

在正在革新癌症治疗方法的纳米医学领域，固体脂质纳米粒（SLN）在临床前研究中对癌细胞的测试显示出优于传统化疗的优势。SLN 已被证明是治疗三阴性乳腺癌细胞的一种创新策略，在各种研究中比现有治疗方法更有效。将抗肿瘤药物包封在 SLN 中促进了持续、控制和靶向释放，从而提高了治疗效率并减少了不良反应。此外，还可以对 SLN 的表面进行修饰以提高效率。例如，用聚乙二醇（PEG）对这些颗粒进行涂层处理可减少其被调理，从而使它们在循环系统中的寿命更长。通过使用带正电荷的结构基团的表面活性剂或离子脂质，可制备带正电荷的阳离子 SLN（cSLN），增加其对细胞膜和血浆蛋白的亲和力。已经将透明质酸添加到 SLN 中，以使肿瘤细胞的独特 pH 值刺激药物和/或遗传物质的释放。本文综述了 SLN 的最新研究进展，重点介绍了对三阴性乳腺癌具有细胞毒性作用的治疗剂的包封和运输。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/53c21b3b3b91/ijms-25-10712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7b21dd6c671a/ijms-25-10712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/15ffd38abdb7/ijms-25-10712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/f6b8769e94c0/ijms-25-10712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/f307b35add51/ijms-25-10712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7fa173232bbb/ijms-25-10712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/312a74ddf126/ijms-25-10712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7f8b3f901e8d/ijms-25-10712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/e83de7345fe5/ijms-25-10712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/53c21b3b3b91/ijms-25-10712-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7b21dd6c671a/ijms-25-10712-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/15ffd38abdb7/ijms-25-10712-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/f6b8769e94c0/ijms-25-10712-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/f307b35add51/ijms-25-10712-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7fa173232bbb/ijms-25-10712-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/312a74ddf126/ijms-25-10712-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/7f8b3f901e8d/ijms-25-10712-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/e83de7345fe5/ijms-25-10712-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d25/11476567/53c21b3b3b91/ijms-25-10712-g009.jpg

相似文献

1
Solid Lipid Nanoparticles, an Alternative for the Treatment of Triple-Negative Breast Cancer.固体脂质纳米粒：三阴性乳腺癌治疗的一种选择。
Int J Mol Sci. 2024 Oct 5;25(19):10712. doi: 10.3390/ijms251910712.
2
Functionalized solid lipid nanoparticles combining docetaxel and erlotinib synergize the anticancer efficacy against triple-negative breast cancer.载药功能性固体脂质纳米粒联合多西他赛和厄洛替尼协同抗三阴性乳腺癌作用
Eur J Pharm Biopharm. 2024 Aug;201:114386. doi: 10.1016/j.ejpb.2024.114386. Epub 2024 Jun 29.
3
DR5 antibody conjugated lipid-based nanocarriers of gamma-secretase inhibitor for the treatment of triple negative breast cancer.DR5 抗体偶联的γ-分泌酶抑制剂脂质纳米载体用于治疗三阴性乳腺癌。
Chem Phys Lipids. 2021 Mar;235:105033. doi: 10.1016/j.chemphyslip.2020.105033. Epub 2020 Dec 29.
4
Lipid nanocarriers of a lipid-conjugated estrogenic derivative inhibit tumor growth and enhance cisplatin activity against triple-negative breast cancer: pharmacokinetic and efficacy evaluation.脂质共轭雌激素衍生物的脂质纳米载体抑制肿瘤生长并增强顺铂对三阴性乳腺癌的活性：药代动力学和疗效评估。
Mol Pharm. 2015 Apr 6;12(4):1105-20. doi: 10.1021/mp5008629. Epub 2015 Mar 2.
5
Anti-CD44 and EGFR Dual-Targeted Solid Lipid Nanoparticles for Delivery of Doxorubicin to Triple-Negative Breast Cancer Cell Line: Preparation, Statistical Optimization, and Characterization.抗 CD44 和 EGFR 双靶固体脂质纳米粒递药系统用于三阴性乳腺癌细胞系的研究：制备、统计优化及表征。
Biomed Res Int. 2022 Jul 6;2022:6253978. doi: 10.1155/2022/6253978. eCollection 2022.
6
Synthetically Lethal BMN 673 (Talazoparib) Loaded Solid Lipid Nanoparticles for BRCA1 Mutant Triple Negative Breast Cancer.载合成致死剂 BMN 673（他拉唑帕利）的固体脂质纳米粒用于 BRCA1 突变型三阴性乳腺癌。
Pharm Res. 2018 Sep 25;35(11):218. doi: 10.1007/s11095-018-2502-6.
7
Talazoparib Loaded Solid Lipid Nanoparticles: Preparation, Characterization and Evaluation of the Therapeutic Efficacy In vitro.他拉唑帕利固体脂质纳米粒的制备、表征及体外治疗效果评价。
Curr Drug Deliv. 2019;16(6):511-529. doi: 10.2174/1567201816666190515105532.
8
Development of pH-Sensitive Cationic PEGylated Solid Lipid Nanoparticles for Selective Cancer-Targeted Therapy.用于选择性癌症靶向治疗的pH敏感型阳离子聚乙二醇化固体脂质纳米粒的研发
J Biomed Nanotechnol. 2017 Feb;13(2):192-03. doi: 10.1166/jbn.2017.2338.
9
Efficient delivery of curcumin by functional solid lipid nanoparticles with promoting endosomal escape and liver targeting properties.具有促进内涵体逃逸和肝脏靶向特性的功能性固体脂质纳米粒高效递送姜黄素。
Colloids Surf B Biointerfaces. 2024 Dec;244:114177. doi: 10.1016/j.colsurfb.2024.114177. Epub 2024 Aug 27.
10
Formulation-optimization of solid lipid nanocarrier system of STAT3 inhibitor to improve its activity in triple negative breast cancer cells.STAT3 抑制剂固体脂质纳米载体系统的配方优化，以提高其在三阴性乳腺癌细胞中的活性。
Drug Dev Ind Pharm. 2019 Feb;45(2):304-313. doi: 10.1080/03639045.2018.1539496. Epub 2018 Nov 8.

引用本文的文献

1
Lycopene as a potential anticancer agent: Current evidence on synergism, drug delivery systems and epidemiology (Review).番茄红素作为一种潜在的抗癌剂：关于协同作用、药物递送系统和流行病学的当前证据（综述）
Oncol Lett. 2025 Jul 28;30(4):462. doi: 10.3892/ol.2025.15208. eCollection 2025 Oct.
2
Advances in plant essential oils and drug delivery systems for skincare.用于护肤品的植物精油及药物递送系统的进展。
Front Pharmacol. 2025 Apr 17;16:1578280. doi: 10.3389/fphar.2025.1578280. eCollection 2025.
3
Nanoparticles of natural product-derived medicines: Beyond the pandemic.

本文引用的文献

1
Functionalized solid lipid nanoparticles combining docetaxel and erlotinib synergize the anticancer efficacy against triple-negative breast cancer.载药功能性固体脂质纳米粒联合多西他赛和厄洛替尼协同抗三阴性乳腺癌作用
Eur J Pharm Biopharm. 2024 Aug;201:114386. doi: 10.1016/j.ejpb.2024.114386. Epub 2024 Jun 29.
2
Site-specific controlled-release nanoparticles for immune reprogramming via dual metabolic inhibition against triple-negative breast cancer.通过双重代谢抑制针对三阴性乳腺癌的免疫重编程的位点特异性控释纳米颗粒。
J Control Release. 2024 Feb;366:204-220. doi: 10.1016/j.jconrel.2023.12.022. Epub 2024 Jan 3.
3
天然产物衍生药物的纳米颗粒：疫情之后
Heliyon. 2025 Feb 19;11(4):e42739. doi: 10.1016/j.heliyon.2025.e42739. eCollection 2025 Feb 28.
4
Ciprofloxacin-encapsulated solid lipid nanoparticles: a comprehensive biochemical analysis of cytotoxic effects, proliferation inhibition, and apoptotic induction in KG1-a leukemia cells.环丙沙星包裹的固体脂质纳米粒：对KG1-a白血病细胞的细胞毒性作用、增殖抑制及凋亡诱导的全面生化分析
Med Oncol. 2025 Feb 13;42(3):75. doi: 10.1007/s12032-025-02619-2.
Quercetin-loaded solid lipid nanoparticles exhibit antitumor activity and suppress the proliferation of triple-negative MDA-MB 231 breast cancer cells: implications for invasive breast cancer treatment.
槲皮素负载固体脂质纳米粒具有抗肿瘤活性，并抑制三阴性 MDA-MB-231 乳腺癌细胞的增殖：对浸润性乳腺癌治疗的意义。
Mol Biol Rep. 2023 Nov;50(11):9417-9430. doi: 10.1007/s11033-023-08848-w. Epub 2023 Oct 13.
4
Advances with Lipid-Based Nanosystems for siRNA Delivery to Breast Cancers.基于脂质的纳米系统用于将小干扰RNA递送至乳腺癌的研究进展
Pharmaceuticals (Basel). 2023 Jul 6;16(7):970. doi: 10.3390/ph16070970.
5
Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy.硫酸软骨素/乳铁蛋白双重功能化白藜芦醇固体脂质纳米粒作为靶向乳腺癌治疗的载体。
Int J Pharm. 2023 Jul 25;642:123163. doi: 10.1016/j.ijpharm.2023.123163. Epub 2023 Jun 21.
6
From Interaction to Intervention: How Mesenchymal Stem Cells Affect and Target Triple-Negative Breast Cancer.从相互作用到干预：间充质干细胞如何影响和靶向三阴性乳腺癌。
Biomedicines. 2023 Apr 15;11(4):1182. doi: 10.3390/biomedicines11041182.
7
Smart Magnetic Drug Delivery Systems for the Treatment of Cancer.用于癌症治疗的智能磁性药物递送系统
Nanomaterials (Basel). 2023 Feb 26;13(5):876. doi: 10.3390/nano13050876.
8
ATP-binding cassette efflux transporters and MDR in cancer.ATP结合盒转运体与癌症中的多药耐药性
Drug Discov Today. 2023 May;28(5):103537. doi: 10.1016/j.drudis.2023.103537. Epub 2023 Feb 16.
9
Folic Acid Functionalized Diallyl Trisulfide-Solid Lipid Nanoparticles for Targeting Triple Negative Breast Cancer.叶酸功能化二烯丙基三硫代-固体脂质纳米粒用于靶向三阴性乳腺癌。
Molecules. 2023 Feb 1;28(3):1393. doi: 10.3390/molecules28031393.
10
Anti-Androgenic Therapies Targeting the Luminal Androgen Receptor of a Typical Triple-Negative Breast Cancer.靶向典型三阴性乳腺癌管腔雄激素受体的抗雄激素疗法
Cancers (Basel). 2022 Dec 30;15(1):233. doi: 10.3390/cancers15010233.