Yin Siliang, Xu Xiuqing, Li Yi, Fang Heng, Ren Junling
Pharmaceutical Research Institute, Guangshengyuan Traditional Chinese Medicine Co., Ltd., Datong, Shanxi 037000, P.R. China.
GAP Center, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, P.R. China.
Oncol Lett. 2025 Jul 28;30(4):462. doi: 10.3892/ol.2025.15208. eCollection 2025 Oct.
Plant-derived natural compounds are an important source of anticancer drugs. Lycopene, commonly referred to as 'plant gold', is a powerful antioxidant with multiple health benefits. It may be associated with a reduction in the morbidity and mortality of several types of cancer, making it a promising anticancer agent. The present review summarizes the synergistic effects of lycopene as a dietary supplement with other chemotherapy drugs or nutrients, for the enhancement of anticancer effects or the reduction of side effects from chemotherapy drugs. Moreover, due to its low water solubility, the development of novel drug delivery systems may improve the bioavailability of lycopene. By summarizing epidemiological research, the present review highlights the current clinical research status and limitations of lycopene, with the aim to provide useful information and guidance for future research on the anticancer effects of lycopene.
植物源天然化合物是抗癌药物的重要来源。番茄红素，通常被称为“植物黄金”，是一种具有多种健康益处的强大抗氧化剂。它可能与几种癌症的发病率和死亡率降低有关，使其成为一种有前景的抗癌剂。本综述总结了番茄红素作为膳食补充剂与其他化疗药物或营养素的协同作用，以增强抗癌效果或减少化疗药物的副作用。此外，由于其低水溶性，新型药物递送系统的开发可能会提高番茄红素的生物利用度。通过总结流行病学研究，本综述突出了番茄红素目前的临床研究现状和局限性，旨在为未来关于番茄红素抗癌作用的研究提供有用的信息和指导。
