Lee Oak-Jin, Han Koeun, Lee Hye-Eun, Jeong Hyo-Bong, Yu Nari, Chae Wonbyoung
Vegetable Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Wanju 55365, Republic of Korea.
Department of Environmental Horticulture, Dankook University, Cheonan 31116, Republic of Korea.
Plants (Basel). 2024 Sep 27;13(19):2708. doi: 10.3390/plants13192708.
Watermelon ( spp.) is an economically important crop globally, but it is susceptible to various diseases, including powdery mildew. Previous studies have identified genetic factors associated with powdery mildew resistance. However, further research using diverse genetic approaches is necessary to elucidate the underlying genetic mechanisms of this resistance. In this study, the germplasm collection comprising highly homozygous inbred lines was employed, which enabled the accumulation of consistent data and improved the reliability of the genome-wide association study (GWAS) findings. Our investigation identified two significant single-nucleotide polymorphisms (SNPs), and , which were strongly associated with disease resistance. Moreover, several candidate genes were revealed within the linkage disequilibrium (LD) blocks surrounding the significant SNPs. In conclusion, the identification of significant SNPs and their additive effects, combined with the discovery of relevant candidate genes, expanded our understanding of the genetic basis of disease resistance and can pave the way for the development of more resilient watermelon cultivars through marker-assisted selection.
西瓜（ 种）是全球一种具有重要经济价值的作物，但它易受多种病害影响，包括白粉病。先前的研究已经确定了与白粉病抗性相关的遗传因素。然而，需要使用多种遗传方法进行进一步研究，以阐明这种抗性的潜在遗传机制。在本研究中，使用了由高度纯合自交系组成的种质库，这使得能够积累一致的数据并提高全基因组关联研究（GWAS）结果的可靠性。我们的调查确定了两个显著的单核苷酸多态性（SNP）， 和 ，它们与抗病性密切相关。此外，在显著SNP周围的连锁不平衡（LD）区域内发现了几个候选基因。总之，显著SNP及其加性效应的鉴定，结合相关候选基因的发现，扩展了我们对抗病性遗传基础的理解，并可为通过标记辅助选择培育更具抗性的西瓜品种铺平道路。
