Plemyashov Kirill, Krutikova Anna, Belikova Angelina, Kuznetsova Tatiana, Semenov Boris
Faculty of Veterinary Medicine, St. Petersburg State University of Veterinary Medicine, 196084 St. Petersburg, Russia.
Animals (Basel). 2024 Sep 27;14(19):2795. doi: 10.3390/ani14192795.
Left displaced abomasum (LDA) is a multifactorial disease of cattle that occurs mainly during the transition postpartum period and is characterized by a decrease in milk production and an increased risk of culling. Several studies have been conducted confirming the hereditary nature of predisposition to this disease. The aim of our study is to identify genetic associations characterizing the genomic variability of susceptibility to LDA in Holstein cattle of the Leningrad region of the Russian Federation. The objects of this study were 360 highly productive dairy cows divided into two groups: animals with LDA, and healthy ones (control). Runs of homozygosity analysis revealed one ROH on BTA13 that was found to be significantly more prevalent in the group of animals with LDA than in the healthy group. Fourteen candidate SNPs were found to be nominally associated with left displacement of the abomasum (-value < 1 × 10). When performing functional annotation of genes containing associated polymorphisms or located close to them, candidate genes presumably associated with the development of LDA were identified: , , , , , , and
左移位真胃（LDA）是奶牛的一种多因素疾病，主要发生在产后过渡期，其特征是产奶量下降和淘汰风险增加。已经进行了几项研究，证实了对这种疾病易感性的遗传性质。我们研究的目的是确定表征俄罗斯联邦列宁格勒地区荷斯坦奶牛对LDA易感性基因组变异的遗传关联。本研究的对象是360头高产奶牛，分为两组：患有LDA的动物和健康动物（对照组）。纯合子片段分析显示，在BTA13上有一个纯合子片段，发现在患有LDA的动物组中比健康组中更为普遍。发现14个候选单核苷酸多态性（SNP）与真胃左移位名义上相关（P值<1×10）。在对含有相关多态性或位于其附近的基因进行功能注释时，确定了可能与LDA发生相关的候选基因： ， ， ， ， ， ，以及
