代谢组学揭示了地锦草皂苷对小鼠糖尿病性高血糖及伤口愈合的影响。
Metabolomics Revealed the Effects of L. Saponins on Diabetic Hyperglycemia and Wound Healing in Mice.
作者信息
Zhao Dengdeng, Luo Zixuan, Li Shasha, Liu Shuwen, Wang Chan
机构信息
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou 510515, China.
出版信息
Foods. 2024 Oct 4;13(19):3163. doi: 10.3390/foods13193163.
L. saponins (MCS) may promote wound-healing properties but the underlying mechanisms are unclear. This study aimed to examine the effects and mechanisms of MCS on diabetic wounds. The results have shown that higher MCS intake lowered fasting blood glucose levels, serum lipids, and lipopolysaccharides in diabetic mice. MCS-treated diabetic mice exhibited faster wound healing than the diabetic control groups. After three days, the diabetic control groups exhibited a wound area reduction of only 19.3%, while a 39.75% reduction was observed following high-dose MCS treatment. Five potential biomarkers were screened in the metabolomics study. The results revealed that MCS mainly regulated glycerophospholipid metabolism, fructose and mannose metabolism, steroid hormone biosynthesis, pyrimidine metabolism, and the Krebs cycle, thus affecting wound healing. Overall, MCS could not only exert a hypoglycemic effect but also promote diabetic wound healing, making it a potential treatment option for diabetes-related wounds.
L. 皂苷（MCS）可能具有促进伤口愈合的特性，但其潜在机制尚不清楚。本研究旨在探讨MCS对糖尿病伤口的影响及机制。结果表明，摄入较高剂量的MCS可降低糖尿病小鼠的空腹血糖水平、血脂和脂多糖。经MCS治疗的糖尿病小鼠伤口愈合速度比糖尿病对照组更快。三天后，糖尿病对照组的伤口面积仅减少了19.3%，而高剂量MCS治疗后伤口面积减少了39.75%。在代谢组学研究中筛选出了五个潜在的生物标志物。结果显示，MCS主要调节甘油磷脂代谢、果糖和甘露糖代谢、类固醇激素生物合成、嘧啶代谢以及三羧酸循环，从而影响伤口愈合。总体而言，MCS不仅能发挥降血糖作用，还能促进糖尿病伤口愈合，使其成为糖尿病相关伤口的一种潜在治疗选择。
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