Grzegorzewski Damian, Sobczak Marharyta, Tołkacz Michał, Pawliczak Rafał
Aurovitas Pharma Poland Ltd., Warsaw, Poland.
Department of Immunopathology, Medical Faculty, Medical University of Lodz, Lodz, Poland.
Front Pharmacol. 2024 Oct 1;15:1340554. doi: 10.3389/fphar.2024.1340554. eCollection 2024.
Allergic rhinitis (AR) is the most common type of rhinitis, the treatment of which relies on relieving symptoms. Therefore, we aimed to assess the criteria that influence doctors' decision-making in the process of drug selection for the treatment of allergic rhinitis based on quantitative, qualitative, and cost analyses.
We conducted a survey study with the participation of 300 allergologists. A self-developed questionnaire was presented during a computer-assisted telephone interview (CATI) according tostandard procedures. The contingency table underwent statistical analysis using the chi-square test with Cramer's V. Results were considered statistically significant at < 0.05.
Our analyses showed that doctors most often prescribe intranasal glucocorticoids and oral antihistamines to treat allergic rhinitis in patients of all ages. The most common factor that affects the decision-making related to AR treatment was the efficiency of the drug. We found a significant relationship between factors and the main workplace (X-squared = 122.81, df = 90, -value = 0.0123, Cramer's V = 0.1787216), as well as voivodeship of the main workplace (X-squared = 440.75, df = 270, -value = 2.378e-10, Cramer's V = 0.1954731). In our study, respondents claimed that patients are willing to pay 31-50 PLN (∼€7- €11) monthly for the treatment of mild and moderate forms of AR, while they were willing to pay 51-100 PLN (∼€11-€22) for treatment of the severe AR form.
Our study confirms that the management of AR should be focused on the patient. One of the most important factors in choosing a drug is its effectiveness. Moreover, an important factor in the effective treatment of AR is the financial issue; as shown in our analysis, AR treatment costs can be a significant burden, especially for less wealthy citizens in Poland.
变应性鼻炎(AR)是最常见的鼻炎类型,其治疗依赖于缓解症状。因此,我们旨在基于定量、定性和成本分析,评估在变应性鼻炎药物选择过程中影响医生决策的标准。
我们开展了一项有300名过敏症专科医生参与的调查研究。根据标准程序,在计算机辅助电话访谈(CATI)期间发放了一份自行编制的问卷。列联表采用卡方检验及克莱姆V系数进行统计分析。结果在P<0.05时被认为具有统计学意义。
我们的分析表明,医生最常为各年龄段的变应性鼻炎患者开具鼻用糖皮质激素和口服抗组胺药。影响变应性鼻炎治疗决策的最常见因素是药物的疗效。我们发现各因素与主要工作场所之间存在显著关系(卡方 = 122.81,自由度 = 90,P值 = 0.0123,克莱姆V = 0.1787216),以及与主要工作场所所在省之间存在显著关系(卡方 = 440.75,自由度 = 270,P值 = 2.378×10⁻¹⁰,克莱姆V = 0.1954731)。在我们的研究中,受访者称患者愿意每月支付31 - 50波兰兹罗提(约7 - 11欧元)用于治疗轻度和中度变应性鼻炎,而对于重度变应性鼻炎,他们愿意支付51 - 100波兰兹罗提(约11 - 22欧元)。
我们的研究证实,变应性鼻炎的管理应以患者为中心。选择药物最重要的因素之一是其有效性。此外,变应性鼻炎有效治疗中的一个重要因素是财务问题;如我们的分析所示,变应性鼻炎的治疗费用可能是一个重大负担,尤其是对波兰较不富裕的公民而言。