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急性白血病呼出气体冷凝物监测——一项试点试验

Exhaled Breath Condensate Surveillance for in Acute Leukemia-a Pilot Trial.

作者信息

Bitterman Roni, Arora Simran, Ng Chun Fai, Walti Laura, Ahmad Syed Zain, Safi Toufik, Gupta Vikas, Husain Shahid

机构信息

Transplant Infectious Diseases, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada.

Division of Infectious Diseases, University Hospital of Bern, Bern, Switzerland.

出版信息

Open Forum Infect Dis. 2024 Sep 24;11(10):ofae537. doi: 10.1093/ofid/ofae537. eCollection 2024 Oct.

DOI:10.1093/ofid/ofae537
PMID:39411227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11475209/
Abstract

Invasive fungal infections in patients with leukemia carry a high mortality rate, but early diagnosis has the potential to modify this natural history. A novel screening method using droplet-digital polymerase chain reaction in exhaled breath condensate may have a similar performance to serum galactomannan screening. Larger studies, including other molds, are necessary.

摘要

白血病患者的侵袭性真菌感染死亡率很高，但早期诊断有可能改变这种自然病程。一种在呼出气冷凝物中使用液滴数字聚合酶链反应的新型筛查方法可能与血清半乳甘露聚糖筛查具有相似的性能。有必要开展包括其他霉菌在内的更大规模研究。

相似文献

1
Exhaled Breath Condensate Surveillance for in Acute Leukemia-a Pilot Trial.急性白血病呼出气体冷凝物监测——一项试点试验
Open Forum Infect Dis. 2024 Sep 24;11(10):ofae537. doi: 10.1093/ofid/ofae537. eCollection 2024 Oct.
2
Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients.对免疫功能低下患者，通过检测呼出气冷凝液中的曲霉菌半乳甘露聚糖与支气管肺泡灌洗液相比，用于诊断侵袭性曲霉菌病。
Clin Microbiol Infect. 2018 Jun;24(6):640-645. doi: 10.1016/j.cmi.2017.09.018. Epub 2017 Sep 29.
3
Superior Accuracy of Aspergillus Plasma Cell-Free DNA Polymerase Chain Reaction Over Serum Galactomannan for the Diagnosis of Invasive Aspergillosis.曲霉血浆细胞游离 DNA 聚合酶链反应对诊断侵袭性曲霉病的准确性优于血清半乳甘露聚糖。
Clin Infect Dis. 2023 Nov 11;77(9):1282-1290. doi: 10.1093/cid/ciad420.
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The IS6110 repetitive DNA element of Mycobacterium tuberculosis is not detected in exhaled breath condensate of patients with active pulmonary tuberculosis.在活动性肺结核患者的呼出气冷凝物中未检测到结核分枝杆菌的IS6110重复DNA元件。
Respiration. 2007;74(3):329-33. doi: 10.1159/000101786.
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Serum galactomannan versus a combination of galactomannan and polymerase chain reaction-based Aspergillus DNA detection for early therapy of invasive aspergillosis in high-risk hematological patients: a randomized controlled trial.血清半乳甘露聚糖与半乳甘露聚糖和聚合酶链反应检测曲霉 DNA 联合用于高危血液病患者侵袭性曲霉病的早期治疗：一项随机对照试验。
Clin Infect Dis. 2015 Feb 1;60(3):405-14. doi: 10.1093/cid/ciu833. Epub 2014 Oct 21.
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Combining standard clinical methods with PCR showed improved diagnosis of invasive pulmonary aspergillosis in patients with hematological malignancies and prolonged neutropenia.将标准临床方法与聚合酶链反应（PCR）相结合，可提高对血液系统恶性肿瘤和长期中性粒细胞减少患者侵袭性肺曲霉病的诊断水平。
BMC Infect Dis. 2015 Jul 1;15:251. doi: 10.1186/s12879-015-0995-8.
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Unsuitability of exhaled breath condensate for the detection of herpesviruses DNA in the respiratory tract.呼气冷凝物不适合用于检测呼吸道中的疱疹病毒 DNA。
J Virol Methods. 2011 May;173(2):384-6. doi: 10.1016/j.jviromet.2011.02.004. Epub 2011 Feb 12.
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Non-invasive detection of Aspergillosis in ventilated patients: Galactomannan analysis in exhaled breath.通气患者侵袭性曲霉病的无创检测：呼出气半乳甘露聚糖分析。
Diagn Microbiol Infect Dis. 2024 Sep;110(1):116420. doi: 10.1016/j.diagmicrobio.2024.116420. Epub 2024 Jun 29.
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'Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid' by Husain, et al.侯赛因等人所著的《与支气管肺泡灌洗液相比较的呼出气冷凝物中半乳甘露聚糖曲霉检测》
Clin Microbiol Infect. 2018 Sep;24(9):1021-1022. doi: 10.1016/j.cmi.2018.04.005. Epub 2018 Apr 11.
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Prospective monitoring for invasive aspergillosis using galactomannan and polymerase chain reaction in high risk pediatric patients.在高危儿科患者中使用半乳甘露聚糖和聚合酶链反应对侵袭性曲霉病进行前瞻性监测。
J Pediatr Hematol Oncol. 2009 Dec;31(12):920-6. doi: 10.1097/MPH.0b013e3181b83e77.

本文引用的文献

1
Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium.侵袭性真菌病的共识定义修订与更新：来自欧洲癌症研究与治疗组织和真菌病研究组教育与研究联合会。
Clin Infect Dis. 2020 Sep 12;71(6):1367-1376. doi: 10.1093/cid/ciz1008.
2
Azole antifungals and new targeted therapies for hematological malignancy.唑类抗真菌药物和血液系统恶性肿瘤的新型靶向治疗。
Curr Opin Infect Dis. 2019 Dec;32(6):538-545. doi: 10.1097/QCO.0000000000000611.
3
Voriconazole Resistance and Mortality in Invasive Aspergillosis: A Multicenter Retrospective Cohort Study.
伏立康唑耐药与侵袭性曲霉病患者死亡率的相关性：一项多中心回顾性队列研究。
Clin Infect Dis. 2019 Apr 24;68(9):1463-1471. doi: 10.1093/cid/ciy859.
4
Aspergillus galactomannan detection in exhaled breath condensate compared to bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in immunocompromised patients.对免疫功能低下患者，通过检测呼出气冷凝液中的曲霉菌半乳甘露聚糖与支气管肺泡灌洗液相比，用于诊断侵袭性曲霉菌病。
Clin Microbiol Infect. 2018 Jun;24(6):640-645. doi: 10.1016/j.cmi.2017.09.018. Epub 2017 Sep 29.
5
Clinical hepatotoxicity associated with antifungal agents.与抗真菌药物相关的临床肝毒性。
Expert Opin Drug Saf. 2017 Feb;16(2):149-165. doi: 10.1080/14740338.2017.1270264. Epub 2016 Dec 16.
6
Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.曲霉病诊断和管理实践指南：美国感染病学会2016年更新版
Clin Infect Dis. 2016 Aug 15;63(4):e1-e60. doi: 10.1093/cid/ciw326. Epub 2016 Jun 29.
7
Survey of antifungal prophylaxis and fungal diagnostic tests employed in malignant haematology and haemopoietic stem cell transplantation (HSCT) in Australia and New Zealand.澳大利亚和新西兰恶性血液学及造血干细胞移植（HSCT）中抗真菌预防措施及真菌诊断检测的调查。
Intern Med J. 2014 Dec;44(12b):1277-82. doi: 10.1111/imj.12594.
8
A breath fungal secondary metabolite signature to diagnose invasive aspergillosis.用于诊断侵袭性曲霉病的呼出真菌次级代谢产物特征。
Clin Infect Dis. 2014 Dec 15;59(12):1733-40. doi: 10.1093/cid/ciu725. Epub 2014 Oct 22.
9
Rapid and specific detection of section Fumigati and Aspergillus fumigatus in human samples using a new multiplex real-time PCR.使用新型多重实时聚合酶链反应快速、特异性检测人体样本中的烟曲霉组和烟曲霉
Diagn Microbiol Infect Dis. 2014 Oct;80(2):111-8. doi: 10.1016/j.diagmicrobio.2014.06.003. Epub 2014 Jun 19.
10
Randomized PCR-based therapy and risk factors for invasive fungal infection following reduced-intensity conditioning and hematopoietic SCT.随机聚合酶链反应为基础的治疗和危险因素的侵袭性真菌感染后，减少强度调理和造血干细胞移植。
Bone Marrow Transplant. 2010 Dec;45(12):1710-8. doi: 10.1038/bmt.2010.38. Epub 2010 Mar 1.