生物标志物在评估儿童重症肺炎严重程度及预后价值中的研究进展
Research progress of biomarkers in evaluating the severity and prognostic value of severe pneumonia in children.
作者信息
Gong Weihua, Gao Kaijie, Shan Zhiming, Yang Liu, Fang Panpan, Li Ci, Yang Junmei, Ni Jiajia
机构信息
Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, Henan, China.
Department of Detection and Diagnosis Technology Research, Guangzhou National Laboratory, Guangzhou, China.
出版信息
Front Pediatr. 2024 Oct 1;12:1417644. doi: 10.3389/fped.2024.1417644. eCollection 2024.
Pneumonia is a serious and common infectious disease in children. If not treated in time, it may develop into severe pneumonia. Severe pneumonia in children is mainly characterized by hypoxia and acidosis, often accompanied by various complications such as sepsis and multiple organ dysfunction. Severe pneumonia has a rapid onset and progression, and a high mortality rate. Biomarkers assist clinicians in the early diagnosis and treatment of patients by quickly and accurately identifying their conditions and prognostic risks. In this study, common clinical and novel biomarkers of severe pneumonia in children were reviewed, and the application value of biomarkers related to the severity and prognosis of severe pneumonia in children was evaluated to provide help for early identification and precise intervention by clinicians.
肺炎是儿童常见的严重传染病。若不及时治疗，可能发展为重症肺炎。儿童重症肺炎主要表现为缺氧和酸中毒，常伴有败血症和多器官功能障碍等各种并发症。重症肺炎起病急、进展快、死亡率高。生物标志物通过快速准确地识别患者病情和预后风险，协助临床医生对患者进行早期诊断和治疗。本研究对儿童重症肺炎的常见临床和新型生物标志物进行综述，评估与儿童重症肺炎严重程度及预后相关生物标志物的应用价值，为临床医生早期识别和精准干预提供帮助。
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