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学龄前儿童额边缘区域的结构发育与脑不对称性

Structural development and brain asymmetry in the fronto-limbic regions in preschool-aged children.

作者信息

Lee Gang Yi, Youn Young-Ah, Jang Yong Hun, Kim Hyuna, Lee Joo Young, Lee Young Jun, Jung Minyoung, Lee Hyun Ju

机构信息

Department of Translational Medicine, Hanyang University Graduate School of Biomedical Science and Engineering, Seoul, Republic of Korea.

Department of Pediatrics, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Republic of Korea.

出版信息

Front Pediatr. 2024 Oct 1;12:1362409. doi: 10.3389/fped.2024.1362409. eCollection 2024.

DOI:10.3389/fped.2024.1362409
PMID:39411282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11473423/
Abstract

Early-life experiences play a crucial role in the development of the fronto-limbic regions, influencing both macro- and microstructural changes in the brain. These alterations profoundly impact cognitive, social-emotional functions. Recently, early limbic structural alterations have been associated with numerous neurological and psychiatric morbidities. Although identifying normative developmental trajectories is essential for determining brain alterations, only a few studies have focused on examining the normative trajectories in the fronto-limbic regions during preschool-aged children. The aim of this study was to investigate the structural-developmental trajectory of the fronto-limbic regions using the cortical thickness, volume, and subcortical volume in 57 healthy and typical preschool-aged children between 1 and 5 years and examined the early lateralization patterns during the development of the fronto-limbic regions. Regarding brain lateralization, remarkable asymmetry was detected in the volume of thalamus and the cortical regions excluding the lateral orbitofrontal cortex in the fronto-limbic regions. This study of preschool-aged children may fill the knowledge gaps regarding the developmental patterns and hemispheric asymmetries of the fronto-limbic regions between newborns and adolescents.

摘要

早期生活经历在额叶 - 边缘系统区域的发育中起着至关重要的作用，影响着大脑的宏观和微观结构变化。这些改变对认知、社会情感功能产生深远影响。最近，早期边缘系统结构改变与多种神经和精神疾病相关。尽管确定正常发育轨迹对于确定大脑改变至关重要，但只有少数研究关注学龄前儿童额叶 - 边缘系统区域的正常轨迹。本研究的目的是利用57名1至5岁健康典型学龄前儿童的皮质厚度、体积和皮质下体积，研究额叶 - 边缘系统区域的结构发育轨迹，并检查额叶 - 边缘系统区域发育过程中的早期偏侧化模式。关于大脑偏侧化，在额叶 - 边缘系统区域的丘脑体积和除外侧眶额叶皮质外的皮质区域中检测到明显的不对称。这项针对学龄前儿童的研究可能填补新生儿和青少年之间额叶 - 边缘系统区域发育模式和半球不对称方面的知识空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/29b4681792bf/fped-12-1362409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/132e24903896/fped-12-1362409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/e7058000cf03/fped-12-1362409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/29b4681792bf/fped-12-1362409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/132e24903896/fped-12-1362409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/e7058000cf03/fped-12-1362409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ab9/11473423/29b4681792bf/fped-12-1362409-g003.jpg

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