Rezaee Arian, Radmanesh Mehrsa, Asghari Atena, Nazari Ahmad, Shahidi Amir Abbas, Chahardehi Amir Modarresi, Arefnezhad Reza, Farkhondeh Tahreh, Saminin Mohammad, Samarghandian Saeed
Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Curr Med Chem. 2024 Oct 14. doi: 10.2174/0109298673311502240930043117.
Glioblastoma (GBM) is a malignant primary brain tumor with a poor prognosis and high recurrence rates. At present, the current treatments available for GBM patients can only prolong their overall survival and cannot provide a complete cure. Discovering an effective therapy against the disease is a challenge due to its recurrence and resistance to common available treatments for GBM. Several natural products have been documented to possess the potential to function as anticancer agents through diverse mechanisms. Astaxanthin (AXT) is an orange-red pigment that is a natural lipophilic and xanthophyll carotenoid derived mostly from microalgae. Numerous studies have examined that AXT impacts GBM cells in laboratory settings and animal models. This review aims to provide the latest information about the potential of astaxanthin as a novel therapeutic option for GBM. AXT has been targeted more on reactive oxygen species (ROS), and suppressed tumor growth in vitro and in vivo conditions. The available data suggests that AXT might serve as a key component in the development of innovative cancer therapies, especially for glioblastoma.
胶质母细胞瘤（GBM）是一种恶性原发性脑肿瘤，预后较差且复发率高。目前，GBM患者可用的现有治疗方法只能延长其总生存期，无法实现完全治愈。由于其复发以及对GBM常用治疗方法的耐药性，找到针对该疾病的有效疗法是一项挑战。有文献记载，几种天然产物具有通过多种机制发挥抗癌剂作用的潜力。虾青素（AXT）是一种橙红色色素，是一种天然的亲脂性叶黄素类胡萝卜素，主要来源于微藻。大量研究在实验室环境和动物模型中检验了AXT对GBM细胞的影响。本综述旨在提供有关虾青素作为GBM新型治疗选择潜力的最新信息。AXT更多地作用于活性氧（ROS），并在体外和体内条件下抑制肿瘤生长。现有数据表明，AXT可能是创新癌症疗法尤其是胶质母细胞瘤疗法开发中的关键成分。
