Department of Radiation Oncology, Karnataka Institute of Medical Science, Hubballi, Karnataka, India.
Department of Radiation Oncology, Ramaiah Medical College, Bengaluru, Karnataka, India.
J Cancer Res Ther. 2024 Jul 1;20(5):1400-1405. doi: 10.4103/jcrt.jcrt_2072_22. Epub 2024 Sep 19.
Superficial lobe constitutes 80% of the parotid and is situated lateral to mandible and can be better spared during intensity modulated radiation therapy (IMRT) for head and neck cancer (HNC). This study aimed to see the impact of bilateral superficial parotid gland (PG) sparing IMRT on xerostomia and quality of life (QOL) in patients with HNC receiving radiation.
Prospective, questionnaire-based study.
Thirty-four patients with histopathologically proven non-nasopharyngeal non-oral cavity HNC were included in this study. IMRT technique was used and a constraint of 24 Gy was given to combined superficial PG. Physician- and patient-rated xerostomia and QOL scores were recorded at baseline and two weeks, three months, and six months post-radiation therapy (RT). The combined superficial PG dose correlated with xerostomia and QOL scores.
The combined superficial PG and combined whole PG mean dose was 18.71 Gy and 30 Gy, respectively, and the difference was statistically significant (P-< 0.001). At two weeks, three months, and six months post-RT, the odds of xerostomia scores were 0.11, 0.071, 0.042, respectively for a median dose of <18 Gy compared to >18 Gy and was statistically significant P=(0.001).
Bilateral superficial PG sparing IMRT is beneficial in reducing xerostomia and translates to a better QOL.
腮腺浅叶占腮腺的 80%，位于下颌骨外侧，在头颈部癌症（HNC）的调强放疗（IMRT）中可以更好地保留。本研究旨在观察双侧腮腺浅叶（PG） spared IMRT 对接受放疗的 HNC 患者口干症和生活质量（QOL）的影响。
前瞻性、基于问卷的研究。
本研究纳入了 34 名经组织病理学证实的非鼻咽非口腔腔隙 HNC 患者。使用调强放疗技术，将联合腮腺浅叶的 24 Gy 作为限制。在基线和放疗后两周、三个月和六个月时记录医生和患者评估的口干症和 QOL 评分。联合腮腺浅叶剂量与口干症和 QOL 评分相关。
联合腮腺浅叶和联合腮腺全叶的平均剂量分别为 18.71 Gy 和 30 Gy，差异具有统计学意义（P-< 0.001）。在放疗后两周、三个月和六个月时，与中位剂量>18 Gy 相比，剂量<18 Gy 的患者口干症评分的可能性分别为 0.11、0.071 和 0.042，差异具有统计学意义（P=0.001）。
双侧腮腺浅叶 sparing IMRT 有助于减少口干症，并提高生活质量。
