West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Institute of Basic Medicine and Forensic Medicine, North Sichuan Medical College, Nanchong 637000, China.
Biomed Pharmacother. 2024 Nov;180:117555. doi: 10.1016/j.biopha.2024.117555. Epub 2024 Oct 15.
Traumatic brain injury (TBI) exhibits high prevalence and mortality, but current treatments remain suboptimal. Traditional Chinese medicine (TCM) has long been effectively used for TBI intervention. Moreover, the recently discovered iron-dependent cell death pathway, known as ferroptosis, characterized by lipid peroxidation, as a key target in TCM-based treatments for TBI. This review provides a comprehensive overview of the latest advancements in TCM strategies targeting ferroptosis in TBI therapy, covering natural product monomers, classic formulas, and acupuncture/moxibustion. The review also addresses current challenges and outlines future research directions to further advance the development and application of TBI management strategies.
创伤性脑损伤（TBI）发病率和死亡率高，但目前的治疗方法仍不尽人意。传统中药（TCM）长期以来一直有效地用于 TBI 干预。此外，最近发现的铁依赖性细胞死亡途径，称为铁死亡，其特征是脂质过氧化，作为 TCM 治疗 TBI 的关键靶点。本综述全面概述了针对 TBI 治疗中铁死亡的 TCM 策略的最新进展，涵盖天然产物单体、经典方剂和针灸/艾灸。该综述还讨论了当前的挑战，并概述了未来的研究方向，以进一步推进 TBI 管理策略的发展和应用。
