Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, People's Republic of China.
Jiangxi Provincial Institute of Parasitic Diseases, Nanchang, 330096, People's Republic of China.
Sci Rep. 2024 Oct 17;14(1):24323. doi: 10.1038/s41598-024-74510-5.
Depression is the second leading-cause of disability in China. Although studies have shown that more than 80% of patients with advanced schistosomiasis (AS) suffer from anxiety and depression, these study groups are all hospitalized patients with AS and do not represent the extent of the disease in the whole group. To our knowledge, there are no studies assessing the severity of depression in patients with other forms of schistosomiasis japonicum. Therefore, it is necessary to evaluate the occurrence and potential risk factors of depression in the schistosomiasis endemic population. This cross-sectional study was conducted in Jiangxi Province, where schistosomiasis is relatively common in China, as the investigation site. The Patient Health Questionnaire-9 (PHQ-9) scale was selected to assess the depressive symptoms in the study population. At the same time, basic personal information of the research subjects and relevant socio-economics and schistosomiasis endemic area indicators were collected. The survey results show that AS has the highest incidence of depression (34.35%), while non-advanced schistosomiasis (N-AS) and control group (CG) have 22.35% and 22.24% respectively; the incidence of depression in AS is significantly higher than in N-AS and CG, while there is no statistical significance in the comparison between N-AS and CG; the incidence of mild depressive symptoms accounts for 61.08%-75.54% of the total incidence of depression in different groups; multivariate analysis shows that the occurrence of moderate/severe depressive symptoms in the AS group was significantly related to above 60 years old, male, the combination of other serious diseases, personal financial difficulties, and marshland and lake endemic areas. In the N-AS group, the occurrence of moderate/severe depressive symptoms was significantly related to the combination of other serious diseases, personal financial difficulties, significant correlation between marshland and lake endemic areas and the level of control of schistosomiasis epidemics. In conclusion, depression is still relatively common among patients with schistosomiasis patients, especially those with AS. It is recommended that the government and relevant departments consider mental health care when developing prevention and control work in schistosomiasis-endemic areas, in order to effectively protect the physical and mental health of schistosomiasis patients and residents in endemic areas.
在中国，抑郁症是导致残疾的第二大主要原因。尽管研究表明，80%以上的晚期血吸虫病（AS）患者患有焦虑和抑郁，但这些研究对象都是住院的 AS 患者，不能代表整个群体的疾病程度。据我们所知，目前尚无研究评估其他类型日本血吸虫病患者的抑郁严重程度。因此，有必要评估流行地区血吸虫病患者抑郁的发生和潜在危险因素。本横断面研究在江西省进行，江西省是中国血吸虫病较为常见的地区，作为调查地点。选择患者健康问卷-9（PHQ-9）量表来评估研究人群的抑郁症状。同时，收集研究对象的基本个人信息和相关社会经济学及血吸虫病流行地区指标。调查结果显示，AS 的抑郁发生率最高（34.35%），而非晚期血吸虫病（N-AS）和对照组（CG）分别为 22.35%和 22.24%；AS 的抑郁发生率明显高于 N-AS 和 CG，而 N-AS 和 CG 之间无统计学意义；不同组别的轻度抑郁症状发生率占总抑郁发生率的 61.08%-75.54%；多因素分析显示，AS 组中中重度抑郁症状的发生与年龄 60 岁以上、男性、其他严重疾病并存、个人经济困难、沼泽和湖泊流行地区有关。在 N-AS 组中，中重度抑郁症状的发生与其他严重疾病并存、个人经济困难、沼泽和湖泊流行地区与血吸虫病流行控制水平显著相关。综上所述，抑郁在血吸虫病患者中仍然较为常见，尤其是 AS 患者。建议政府和相关部门在制定血吸虫病流行地区的防治工作时考虑心理健康护理，以有效保护血吸虫病患者和流行地区居民的身心健康。
