Department of Biological Sciences, Superior University, Lahore, 53700, Pakistan.
Division of Molecular Virology, Center of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan.
BMC Public Health. 2024 Oct 16;24(1):2842. doi: 10.1186/s12889-024-20331-0.
There are reported studies of Hepatitis C and chronic kidney disease association. However, how this liver virus infection affects the general population's susceptibility to the onset of the kidney disease is still unknown.
To determine if a positive anti-HCV serologic status is linked to a greater incidence of chronic kidney disease in the general adult population, a systematic evaluation of the published medical literature since 2015 was conducted. A summary estimate of the relative risk of chronic kidney disease with HCV was produced using a random-effects model. Moreover, stratified analysis and meta-regression were performed.
Twelve studies (n = 605858 patients) were filtered and included. Meta-analyses were conducted according to the outcome. Pooling results of longitudinal studies (n = 06 studies, n = 347120 unique patients) demonstrated an association between positive anti-HCV serologic status and increased incidence of CKD. The summary estimate for adjusted hazard ratio was 1.21 with (95% confidence interval 1.13; 1.29, P = 0.001), and between studies heterogeneity was noted (P value by Q test < 0.001). In the subset of Asian surveys, the risk of the occurrence of chronic kidney disease linked to HCV was 1.70 (95% confidence interval 1.40; 2.00) without heterogeneity (P value by Q test = 0.6).
We found a strong correlation between HCV infection and a higher risk of chronic renal disease in general global population.
有报道称丙型肝炎和慢性肾病之间存在关联。然而，这种肝病毒感染如何影响普通人群患肾病的易感性尚不清楚。
为了确定抗 HCV 血清阳性状态是否与普通成年人群中慢性肾脏病的发病率增加有关，对 2015 年以来发表的医学文献进行了系统评价。使用随机效应模型对 HCV 相关慢性肾脏病的相对风险进行了汇总估计。此外，还进行了分层分析和荟萃回归。
筛选并纳入了 12 项研究（n=605858 例患者）。根据结局进行了荟萃分析。对纵向研究（n=06 项研究，n=347120 例独特患者）的汇总结果表明，抗 HCV 血清阳性状态与 CKD 发生率增加之间存在关联。调整后的危险比的汇总估计值为 1.21（95%置信区间 1.13；1.29，P=0.001），且研究间存在异质性（Q 检验 P 值<0.001）。在亚洲调查的亚组中，与 HCV 相关的慢性肾脏病发生风险为 1.70（95%置信区间 1.40；2.00），无异质性（Q 检验 P 值=0.6）。
我们发现 HCV 感染与普通全球人群慢性肾脏病风险增加之间存在很强的相关性。
