Salari Nader, Kazeminia Mohsen, Hemati Niloufar, Ammari-Allahyari Mojtaba, Mohammadi Masoud, Shohaimi Shamarina
Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Travel Med Infect Dis. 2022 Mar-Apr;46:102255. doi: 10.1016/j.tmaid.2022.102255. Epub 2022 Jan 8.
According to published reports from the World Health Organization, it is estimated that more than 3% of the world's population is infected with HCV. Given the impact of various factors on the prevalence of HCV in the world's population and the lack of general statistics around the world, this study aims to review the studies conducted in this field and statistical analysis of the results of general statistical studies on the prevalence of HCV in the world population.
In this study, systematic review and meta-analysis of information of the studies related to the prevalence of HCV in the world using keywords including: Prevalence, HCV, Hepatitis C, Healthy Population, Healthy subjects, and General Population in SID, MagIran, IranMedex, IranDoc, ScienceDirect, Embase, Scopus, PubMed, Web of Science (WoS) databases and Google Scholar search engine were extracted without time limit until April 2020. In order to perform the analysis of qualified studies, the model of random effects was used, and the inconsistency of studies with I index was investigated. Data analysis was performed with Comprehensive Meta-Analysis (Version 2).
In a study of 98 studies with a total sample size of 236,964 people in the world, the overall prevalence of HCV was 1.8% (95% CI: 1.4%-2.3%). Also, according to the subgroup analysis in different continents; the highest prevalence of HCV in the African continent was 7.1% (95% CI: 4.4-11.5%).
The results of this study show that the prevalence of hepatitis C in the world's population, especially in Africa, is almost high. Therefore, the officials of the World Health Organization should design measures to prevent the spread of this infection.
根据世界卫生组织发布的报告估计，全球超过3%的人口感染了丙肝病毒。鉴于各种因素对全球人口中丙肝病毒流行率的影响以及全球缺乏总体统计数据，本研究旨在回顾该领域已开展的研究，并对全球人口丙肝病毒流行率的总体统计研究结果进行统计分析。
在本研究中，通过使用关键词“流行率”“丙肝病毒”“丙型肝炎”“健康人群”“健康受试者”“普通人群”，在伊朗科学信息数据库（SID）、伊朗医学数据库（MagIran）、伊朗医学索引数据库（IranMedex）、伊朗文献数据库（IranDoc）、科学Direct数据库、Embase数据库、Scopus数据库、PubMed数据库、科学网（WoS）数据库以及谷歌学术搜索引擎中，无时间限制地提取截至2020年4月与全球丙肝病毒流行率相关的研究信息。为了对合格研究进行分析，采用随机效应模型，并研究I指数所反映的研究不一致性。使用综合荟萃分析（版本2）进行数据分析。
在一项对全球98项研究的分析中，总样本量为236,964人，丙肝病毒的总体流行率为1.8%（95%置信区间：1.4%-2.3%）。此外，根据不同大陆的亚组分析；非洲大陆丙肝病毒的最高流行率为7.1%（95%置信区间：4.4-11.5%）。
本研究结果表明，全球人口中丙型肝炎的流行率，尤其是在非洲，几乎很高。因此，世界卫生组织的官员应制定措施来预防这种感染的传播。
