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斯洛文尼亚循环死亡后不受控制的捐献潜力可增加器官捐献:SiOHCA 研究数据的推断。

Uncontrolled Donation Potential After Circulatory Death in Slovenia Could Lead to More Organ Donations: Extrapolation of SiOHCA Study Data.

机构信息

General Hospital of Novo mesto, Novo mesto, Slovenia.

University Medical Center Maribor, Maribor, Slovenia.

出版信息

Inquiry. 2024 Jan-Dec;61:469580241283185. doi: 10.1177/00469580241283185.

DOI:10.1177/00469580241283185
PMID:39415366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11487513/
Abstract

Out-of-hospital cardiac arrest is one of the major health challenges faced by developed countries. Donation after circulatory death is a process of retrieving organs from individuals whose death has been confirmed by circulatory or respiratory criteria. In 2018, 136 625 people were listed on the waitlist covering over 16 countries. Out of these 136 625 individuals, 7383 died whilst waiting that year. The aim of this study is to assess the potential for the uncontrolled donation after circulatory death among out-of-hospital cardiac arrest patients in Slovenia. This non-interventional study was conducted using the Slovenian out-of-hospital cardiac arrest registry dataset. The database measured Out-of-hospital cardiac arrest in Slovenia between September and November 2022. From the database we chose patients who would be identified as donors by the uncontrolled donation after circulatory death guidelines for patient selection. Using the selection criteria we have narrowed the used data set from 294 unique patient records to 19. There were no organ donors in the cohort. With extrapolation we calculated that in 2022 there could be 111 donors in Slovenia that would fit the uncontrolled donation after circulatory death criteria. This equates to 52.4 pmp/y. We conclude that uncontrolled donation after circulatory death program in Slovenia would positively impact patients. Although our study is limited by a small sample of out-of-hospital cardiac arrest patients and short duration of the Slovenian out-of-hospital cardiac arrest registry inclusion, the results offer a good foundation to further explore uncontrolled organ donation in Slovenia and similar countries.

摘要

院外心脏骤停是发达国家面临的主要健康挑战之一。循环死亡后捐献是从已通过循环或呼吸标准确认死亡的个体中获取器官的过程。2018 年,有 136625 人在涵盖超过 16 个国家的等待名单上。在这些 136625 人中,当年有 7383 人在等待中死亡。本研究旨在评估斯洛文尼亚院外心脏骤停患者中循环死亡后不受控制捐献的潜力。这项非干预性研究使用了斯洛文尼亚院外心脏骤停登记数据库进行。该数据库测量了 2022 年 9 月至 11 月期间斯洛文尼亚的院外心脏骤停。从数据库中,我们选择了那些将根据循环死亡后不受控制捐献的指南被确定为捐献者的患者。使用选择标准,我们将使用的数据组从 294 个独特的患者记录缩小到 19 个。该队列中没有器官捐献者。通过推断,我们计算出 2022 年斯洛文尼亚可能有 111 名符合循环死亡后不受控制捐献标准的捐献者。这相当于 52.4 pmp/y。我们得出结论,斯洛文尼亚的循环死亡后不受控制的捐献计划将对患者产生积极影响。尽管我们的研究受到院外心脏骤停患者样本量小和斯洛文尼亚院外心脏骤停登记册纳入时间短的限制,但结果为进一步探索斯洛文尼亚和类似国家的不受控制的器官捐献提供了良好的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b7/11487513/c023cde278ee/10.1177_00469580241283185-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b7/11487513/afbd3c8e6491/10.1177_00469580241283185-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b7/11487513/c023cde278ee/10.1177_00469580241283185-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b7/11487513/afbd3c8e6491/10.1177_00469580241283185-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8b7/11487513/c023cde278ee/10.1177_00469580241283185-fig2.jpg

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本文引用的文献

1
OHCA in Bosnia and Herzegovina: Before and During the COVID-19 Pandemic.波斯尼亚和黑塞哥维那的院外心脏骤停:新冠疫情之前及期间
Mater Sociomed. 2024;36(1):4-9. doi: 10.5455/msm.2024.36.4-9.
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OUT-OF-HOSPITAL CARDIAC ARREST OUTCOMES - BYSTANDER CARDIOPULMONARY RESUSCITATION RATE IMPROVEMENT.院外心脏骤停结局-旁观者心肺复苏率提高。
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Organ donation after out-of-hospital cardiac arrest: a population-based study of data from the Paris Sudden Death Expertise Center.
院外心脏骤停后的器官捐献:一项基于巴黎猝死专家中心数据的人群研究。
Ann Intensive Care. 2022 Jun 6;12(1):48. doi: 10.1186/s13613-022-01023-7.
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Potential of Donation After Unexpected Circulatory Death Programs Defined by Their Demographic Characteristics.根据人口统计学特征定义的意外循环性死亡后捐赠项目的潜力。
Transplant Direct. 2021 Dec 23;8(1):e1263. doi: 10.1097/TXD.0000000000001263. eCollection 2022 Jan.
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Between-hospital variability in organ donation after resuscitation from out-of-hospital cardiac arrest.院外心脏骤停复苏后器官捐献的医院间差异。
Resuscitation. 2021 Oct;167:372-379. doi: 10.1016/j.resuscitation.2021.07.038. Epub 2021 Aug 4.
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Scand J Trauma Resusc Emerg Med. 2021 Jul 28;29(1):105. doi: 10.1186/s13049-021-00924-z.
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Organ donation in the US and Europe: The supply vs demand imbalance.美国和欧洲的器官捐赠:供需失衡。
Transplant Rev (Orlando). 2021 Apr;35(2):100585. doi: 10.1016/j.trre.2020.100585. Epub 2020 Oct 11.
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