Benova D K
Mutat Res. 1986 Jan-Feb;159(1-2):75-81. doi: 10.1016/0027-5107(86)90114-4.
The radioprotective drugs AET, serotonin, and ATP were tested for antimutagenic activity against induction by 4.0 Gy X-rays of reciprocal translocations in mouse spermatogonia. Single drugs administered in doses of 8, 24 and 360 mg/kg b.wt., respectively, had no effect on translocation yields recorded in diakinesis-metaphase I spermatocytes. Two-drug mixtures afforded insignificant protection. Three-drug mixtures, however, were found to reduce radiation damage considerably, and the extent of protection was dependent in part on the amount of ATP. The best effect was obtained with formulations of serotonin-AET-ATP at the following doses, respectively: 8 + 24 + 360 mg/kg, 16 + 24 + 336 mg/kg, and 16 + 32 + 264 mg/kg. Less effective were the serotonin-AET-ATP formulations: 16 + 32 + 120 mg/kg, and 8 + 24 + 480 mg/kg. Treatment with drugs omitting radiation exposure was observed to raise, though insignificantly, the level of spontaneous translocation frequency.
对放射防护药物氨乙基异硫脲（AET）、血清素和三磷酸腺苷（ATP）进行了测试，以检测其对4.0 Gy X射线诱导小鼠精原细胞相互易位的抗诱变活性。分别以8、24和360 mg/kg体重的剂量施用单一药物，对在减数分裂终变期-中期I精母细胞中记录的易位产率没有影响。两种药物的混合物提供的保护作用不显著。然而，发现三种药物的混合物能显著降低辐射损伤，保护程度部分取决于ATP的量。分别以以下剂量的血清素-AET-ATP制剂获得了最佳效果：8 + 24 + 360 mg/kg、16 + 24 + 336 mg/kg和16 + 32 + 264 mg/kg。血清素-AET-ATP制剂8 + 24 + 480 mg/kg和16 + 32 + 120 mg/kg的效果较差。观察到在不进行辐射暴露的情况下用药物治疗会使自发易位频率水平略有升高。
