Pomerantseva M D, Ramaija L K
Mutat Res. 1984 Jun-Jul;140(2-3):131-5. doi: 10.1016/0165-7992(84)90057-5.
A study was made of the protective effect of some radioprotective agents against dominant lethal mutations (DLM) in postspermatogonial stages and reciprocal translocations (RT) in spermatogonia induced by gamma-radiation. Among the radioprotective agents used, cystaphos, a combination of cystamine and 5-MOT and a mixture of 6 components proved to be most effective against DLM, and cystaphos, gammaphos and cystamine combined with 5-MOT proved effective against RT. The degree of radioprotective efficacy was relatively low. The efficacy of cystamine in protecting against RT was higher with exposure of gonocytes of 18.5-day embryos than spermatogonia of pubertal animals. The degree of the radioprotective effect varied depending on the stage of spermatogenesis, and, in all cases, it was lower than that observed in studies of protection against lethal effects of ionizing radiation.
对某些辐射防护剂对γ射线诱导的精原细胞后期显性致死突变（DLM）和精原细胞相互易位（RT）的防护作用进行了研究。在所使用的辐射防护剂中，胱胺磷、胱胺与5 - MOT的组合以及一种6组分混合物对DLM最为有效，而胱胺磷、γ - 磷和胱胺与5 - MOT的组合对RT有效。辐射防护效果的程度相对较低。与青春期动物的精原细胞相比，18.5天胚胎的生殖细胞暴露时，胱胺对RT的防护效果更高。辐射防护作用的程度因精子发生阶段而异，并且在所有情况下，均低于针对电离辐射致死效应防护研究中观察到的程度。
