Violetti Silvia Alberti, Ardigò Marco, Fava Paolo, Gritti Giuseppe, Morsia Erika, Onida Francesco, Paulli Marco, Pileri Alessandro, Quaglino Pietro, Rupoli Serena, Teoli Miriam, Vezzoli Pamela
Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Drugs Context. 2024 Oct 10;13. doi: 10.7573/dic.2024-6-1. eCollection 2024.
Topical chlormethine (CL) gel formulation was approved by the EMA in 2017 for the treatment of adult patients with mycosis fungoides (MF). To expand the knowledge on the management of MF, this paper provides an overview of clinical practice evidence about the MF diagnostic phase and a collection of clinical experiences to better characterize the use of CL gel in daily practice. Collected cases underline the importance of the concomitant biopsy and clinical evaluation in the diagnostic phase, with the contribution of a multidisciplinary team, and support the use of CL gel as a first-line or adjuvant treatment in selected patients.
外用氮芥（CL）凝胶制剂于2017年获欧洲药品管理局（EMA）批准，用于治疗成年蕈样肉芽肿（MF）患者。为拓展对MF治疗的认识，本文概述了MF诊断阶段的临床实践证据，并收集了临床经验，以更好地描述CL凝胶在日常实践中的应用。收集的病例强调了在诊断阶段进行同步活检和临床评估的重要性，以及多学科团队的贡献，并支持将CL凝胶作为特定患者的一线或辅助治疗方法。
