Feller D D, Neville E D, Keil L C, Ellis S
Physiol Chem Phys. 1979;11(3):205-15.
An in vivo response of glucose oxidation to growth hormone has been demonstrated. Hypophysectomized rats were found to oxidize glucose at rates significantly higher than normal rats. Treatment with growth hormone 1 h before injection of 14C-U-glucose, 14C-6-glucose, or 14C-1-glucose caused a return to a normal oxidation pattern. This acute response was independent of insulin action but clearly time-dependent since no change from untreated hypophysectomized rats appeared when growth hormone was given at various times prior to administration of labeled glucose. The response observed for 14C-6-glucose was comparable to that observed for 14C-1-glucose with regard to dynamics but differed with respect to total 14C recovered as 14CO2. The cumulative percent 14CO2 recovered from oxidation of 14C-6-glucose 1 h after growth hormone injection exceeded that recovered from oxidation of 14C-1-glucose. These results suggest a change in glucose oxidation by a route that cannot be explained solely by changes in either the hexose monophosphate or Embden-Meyerhof pathways.
已证实葡萄糖氧化对生长激素的体内反应。发现垂体切除的大鼠氧化葡萄糖的速率明显高于正常大鼠。在注射14C-U-葡萄糖、14C-6-葡萄糖或14C-1-葡萄糖前1小时用生长激素治疗，可使氧化模式恢复正常。这种急性反应与胰岛素作用无关，但明显具有时间依赖性，因为在给予标记葡萄糖之前的不同时间给予生长激素时，未处理的垂体切除大鼠没有出现变化。就动力学而言，观察到的14C-6-葡萄糖的反应与14C-1-葡萄糖的反应相当，但在作为14CO2回收的总14C方面有所不同。生长激素注射1小时后，从14C-6-葡萄糖氧化中回收的14CO2累积百分比超过了从14C-1-葡萄糖氧化中回收的百分比。这些结果表明葡萄糖氧化途径发生了变化，这不能仅通过己糖磷酸途径或糖酵解途径的变化来解释。
