通过对垂体切除大鼠体内L-鸟氨酸-1-14C的氧化反应所证实的鸟氨酸脱羧酶活性对生长激素的体内反应。
In vivo response of ornithine decarboxylase activity to growth hormone as demonstrated by oxidation of L-ornithine-1-14C in hypophysectomized rats.
作者信息
Feller D D, Neville E D, Ellis S
出版信息
Physiol Chem Phys. 1977;9(1):55-61.
PMID:909953
Abstract
An in vivo response of ornithine decarboxylase activity to growth hormone has been demonstrated. In hypophysectomized rats, found to oxidize ornithine at rates comparable to those of normal rats, an acute treatment of growth hormone 4 hours before injection of L-ornithine-1-14C caused a 39% increase in the peak specific activity of carbon dioxide and a 24% increase in the 14CO2 recovered in 5 hours. However, response was not observed when growth hormone was administered chronically rather than acutely.
摘要
已证实鸟氨酸脱羧酶活性对生长激素的体内反应。在垂体切除的大鼠中，发现其氧化鸟氨酸的速率与正常大鼠相当，在注射L-鸟氨酸-1-¹⁴C前4小时急性给予生长激素，可使二氧化碳的峰值比活性增加39%，并使5小时内回收的¹⁴CO₂增加24%。然而，当长期而非急性给予生长激素时，未观察到反应。
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