Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Brain Behav. 2024 Oct;14(10):e70106. doi: 10.1002/brb3.70106.
Chronic kidney disease (CKD) is increasingly recognized as a risk factor for alterations in brain function. However, detecting early-stage symptoms and structural changes remains challenging, potentially leading to delayed treatment. In our study, we aimed to investigate spontaneous brain activity changes in CKD patients using resting-state functional magnetic resonance imaging (fMRI). Additionally, we explored the correlation between common biomarkers reflecting CKD severity and brain activity.
We recruited a cohort of 22 non-dialysis-dependent CKD patients and 22 controls for resting-state fMRI scans. Amplitude of low-frequency fluctuations (ALFFs) and regional homogeneity (ReHo) were calculated to evaluate brain activity. Regression analysis was conducted to explore the correlations between biomarkers reflecting the severity of CKD and brain activity.
CKD patients exhibited reduced z-scored ALFF (zALFF) and mean ALFF (mALFF) in the bilateral putamen, right caudate nucleus, left anterior cingulate, and right precuneus. Changes in bilateral putamen were also found in smCohe-ReHo and szCohe-ReHo analyses. Urine albumin-to-creatinine ratio (UACR), urine protein-to-creatinine ratio (UPCR), and serum albumin levels were associated with attenuated putamen activity.
Non-dialysis-dependent CKD patients had changes in zALFF, mALFF, smCohe-ReHo, and szCohe-ReHo values in specific brain regions, especially bilateral putamen. UACR, UPCR, and serum albumin levels are associated with putamen activity attenuation in rs-fMRI.
慢性肾脏病（CKD）日益被认为是大脑功能改变的危险因素。然而，检测早期症状和结构变化仍然具有挑战性，这可能导致治疗延迟。在我们的研究中，我们旨在使用静息态功能磁共振成像（rs-fMRI）研究 CKD 患者的自发性脑活动变化。此外，我们还探讨了反映 CKD 严重程度的常见生物标志物与脑活动之间的相关性。
我们招募了 22 名非透析依赖性 CKD 患者和 22 名对照进行 rs-fMRI 扫描。计算幅度低频波动（ALFF）和局部一致性（ReHo）来评估脑活动。进行回归分析以探讨反映 CKD 严重程度的生物标志物与脑活动之间的相关性。
CKD 患者双侧壳核、右侧尾状核、左侧前扣带回和右侧楔前叶的 z 得分 ALFF（zALFF）和平均 ALFF（mALFF）降低。在 smCohe-ReHo 和 szCohe-ReHo 分析中也发现双侧壳核的变化。尿白蛋白与肌酐比值（UACR）、尿蛋白与肌酐比值（UPCR）和血清白蛋白水平与壳核活性降低有关。
非透析依赖性 CKD 患者在特定脑区出现 zALFF、mALFF、smCohe-ReHo 和 szCohe-ReHo 值变化，尤其是双侧壳核。UACR、UPCR 和血清白蛋白水平与 rs-fMRI 中壳核活性降低有关。
