The University of Texas Health Science Center at Houston, Children's Memorial Hermann Hospital, Houston, TX, 77030, USA.
Division of Clinical and Translational Sciences, Department of Internal Medicine, the University of Texas McGovern Medical School at Houston, Houston, TX, 77030, USA.
Eur J Pediatr. 2024 Dec;183(12):5425-5439. doi: 10.1007/s00431-024-05818-7. Epub 2024 Oct 17.
Normative values for intracardiac and extracardiac vascular structures help in understanding normal growth and changes over time in children; this normative data is not currently available for ECG-gated computed tomography angiography (CTA). We sought to establish ECG-gated CTA-derived normative values for the aortic root, aorta, and aortic arch in children. Aortic root, ascending aorta, aortic arch, and descending aorta were measured in systole and diastole in 100 subjects who had ECG-gated CTA at our center between January 2015 and December 2020 and met our inclusion criteria. The allometric exponent (AE) for each parameter was derived, and the parameter/body surface area (BSA) was established using the previously described methods. Using this data, normalized mean, cross-sectional area, and standard deviation were calculated. Z-score curves were plotted in relation to the BSA for all measurements.
Our study reports systolic and diastolic ECG-gated CTA Z-scores along with normative curves in relation to BSA for the aortic root, aorta, and aortic arch in children.
• Normative data for intracardiac and extracardiac vascular structures in the pediatric population are available for echocardiography, cardiac MRI and non-ECG gated CTA. • Z-scores with standard deviations are commonly used in children, but SDs are not constant across body sizes due to heteroscedasticity.
• Allometric exponent was derived for each parameter and the parameter/body surface area (BSA) was established. • This is the first ECG-gated CTA study to provide normative en face systolic, diastolic diameters and cross-sectional areas along with Z-scores and normative curves for the aortic root, aorta and aortic arch in children.
目的：本研究旨在建立儿童心脏门控 CT 血管造影（CTA）的升主动脉根部、升主动脉、主动脉弓和降主动脉的正常参考值。
方法：对 2015 年 1 月至 2020 年 12 月期间在我院接受心脏门控 CTA 检查且符合纳入标准的 100 例患者进行回顾性分析。在收缩期和舒张期测量升主动脉根部、升主动脉、主动脉弓和降主动脉。采用既往描述的方法，得出各参数的幂指数（AE），并建立参数/体表面积（BSA）。采用该数据计算标准化均值、横截面积和标准差。绘制与 BSA 相关的所有测量值的 Z 评分曲线。
结果：本研究报告了与 BSA 相关的儿童升主动脉根部、升主动脉、主动脉弓的心脏门控 CTA 收缩期和舒张期 Z 评分以及正常曲线。
结论：本研究首次提供了儿童升主动脉根部、升主动脉、主动脉弓的心脏门控 CTA 正常参考值的面心收缩、舒张直径和横截面积，以及 Z 评分和正常曲线。
