Murphy J, Murphy S F
Neurology. 1986 Jan;36(1):78-80. doi: 10.1212/wnl.36.1.78.
The literature records myasthenia gravis in five sets of monozygous twins; we report another pair in which monozygosity was determined by blood group analysis, HLA typing, and mixed lymphocyte culture. Acetylcholine receptor antibodies were strongly positive in both twins. Poor response to anticholinergic medication and thymectomy necessitates low-dose daily maintenance prednisone for a normal life-style. The probability of myasthenia developing in the unaffected monozygotic twin is highest soon after diagnosis in the proband and an unaffected twin should be followed indefinitely.
文献记载了五对单卵双胞胎患重症肌无力的情况；我们报告另一对单卵双胞胎，其单合子性是通过血型分析、HLA分型和混合淋巴细胞培养确定的。乙酰胆碱受体抗体在这对双胞胎中均呈强阳性。对抗胆碱能药物和胸腺切除术反应不佳，因此需要每日服用低剂量泼尼松进行维持治疗，以维持正常生活方式。在先证者被诊断后不久，未受影响的单卵双胞胎发生重症肌无力的可能性最高，应对未受影响的双胞胎进行长期随访。
