Stark D D, Wittenberg J, Middleton M S, Ferrucci J T
Radiology. 1986 Feb;158(2):327-32. doi: 10.1148/radiology.158.2.3941859.
Forty patients with biopsy-proved metastatic liver cancers were studied by magnetic resonance (MR) imaging using one or more conventional (in-phase) pulse sequences and a corresponding phase-contrast (opposed-phase) pulse sequence. Pulse-sequence performance was quantitated by measuring signal-difference-to-noise (SD/N) ratios between cancerous tissue and liver. The SD/N performance of T2-weighted spin-echo (SE) pulse sequences improved when used with the phase-contrast technique. SE 2,000/30 opposed-phase images showed improved (P less than .001) SD/N in 72% of patients over in-phase images. The SD/N of T1-weighted SE or inversion recovery pulse sequences deteriorated when used with the phase-contrast technique. Changes in measured SD/N correlated well with image appearance and actual lesion detectability in individual cases. Phase-contrast imaging should be employed routinely when T2-weighted SE pulse sequences are relied on to detect liver cancer.
对40例经活检证实为转移性肝癌的患者进行了磁共振（MR）成像研究，使用了一种或多种传统（同相位）脉冲序列和相应的相位对比（反相位）脉冲序列。通过测量癌组织与肝脏之间的信号差与噪声比（SD/N）来定量脉冲序列性能。当与相位对比技术一起使用时，T2加权自旋回波（SE）脉冲序列的SD/N性能得到改善。与同相位图像相比，SE 2000/30反相位图像在72%的患者中显示出改善（P<0.001）的SD/N。当与相位对比技术一起使用时，T1加权SE或反转恢复脉冲序列的SD/N恶化。在个别病例中，测量的SD/N变化与图像外观和实际病变可检测性密切相关。当依靠T2加权SE脉冲序列检测肝癌时，应常规采用相位对比成像。
