Jakimovski Dejan, Zivadinov Robert, Ramanathan Murali, Weinstock-Guttman Bianca, Tavazzi Eleonora, Dwyer Michael G, Bergsland Niels
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, 100 High St, Buffalo, NY, 14203, USA.
Wynn Hospital, Mohawk Valley Health System, Utica, NY, 13502, USA.
J Neurovirol. 2024 Dec;30(5-6):545-549. doi: 10.1007/s13365-024-01231-w. Epub 2024 Oct 17.
Choroid plexus (CP) inflammation can be quantified in vivo with MRI in people with multiple sclerosis (pwMS). It remains unknown whether Epstein Barr Virus (EBV) is related to CP changes. Total of 170 pwMS (116 relapsing-remitting; RRMS and 54 progressive MS; PMS) underwent MRI examination and measurement of humoral anti-EBV response. CP volume and CP pseudo-T2 (pT2), a relaxation time indicative of edema and neuroinflammation, were measured. Moreover, anti-EBV nuclear antigen-1 (EBNA-1) IgG and anti-EBV capsid antigen (VCA) IgG antibodies were measured. The PMS group had greater CP pT2 value when compared to RRMS (1120ms vs. 954ms, p = 0.037). After adjusting for age and therapy effects, higher CP pT2 values were associated with higher anti-EBNA-1 IgG levels only in PMS (r = 0.352, p = 0.015). Higher Anti-EBV humoral response in pwMS may be associated with increased CP neuroinflammatory changes and may be more relevant for the later chronic stage of the disease. Large-scale studies should investigate whether these findings are generalizable to all types of progressive MS.
脉络丛（CP）炎症可通过磁共振成像（MRI）在体内对多发性硬化症患者（pwMS）进行量化。目前尚不清楚爱泼斯坦-巴尔病毒（EBV）是否与CP变化有关。共有170例pwMS患者（116例复发缓解型；RRMS和54例进展型MS；PMS）接受了MRI检查和体液抗EBV反应测量。测量了CP体积和CP伪T2（pT2），pT2是一种指示水肿和神经炎症的弛豫时间。此外，还测量了抗EBV核抗原-1（EBNA-1）IgG和抗EBV衣壳抗原（VCA）IgG抗体。与RRMS相比，PMS组的CP pT2值更高（1120ms对954ms，p = 0.037）。在调整年龄和治疗效果后，仅在PMS中，较高的CP pT2值与较高的抗EBNA-1 IgG水平相关（r = 0.352，p = 0.015）。pwMS中较高的抗EBV体液反应可能与CP神经炎症变化增加有关，并且可能与疾病后期的慢性阶段更相关。大规模研究应调查这些发现是否适用于所有类型的进展型MS。
