多囊卵巢综合征患者血脂异常与全身免疫炎症指数的相关性及预测价值。
Correlation and predictive value of systemic immune-inflammation index for dyslipidemia in patients with polycystic ovary syndrome.
机构信息
The First Clinical Medical College of Lanzhou University, Lanzhou, China.
The Basic Medical College of Lanzhou University, Lanzhou, China.
出版信息
BMC Womens Health. 2024 Oct 17;24(1):564. doi: 10.1186/s12905-024-03405-4.
BACKGROUND
Polycystic ovary syndrome(PCOS) is one of the main factors leading to infertility in women of reproductive age, which is often accompanied by metabolic changes such as obesity and chronic low-grade inflammation. Chronic inflammation may play an important role in the occurrence and development of metabolic diseases. Therefore, it is of great significance to explore the relationship between abnormal lipid metabolism and inflammation in PCOS patients. This study aims to analyze the correlation between systemic immune-inflammatory(SII) markers and dyslipidemia in patients with PCOS and their value in early diagnosis.
METHODS
A total of 617 PCOS patients aged 20-35 years (according to the Rotterdam diagnostic criteria) who visited the Reproductive Center of the First Hospital of Lanzhou University from January 2020 to December 2022 were included. According to the presence or absence of dyslipidemia, the patients were divided into normal lipid metabolism group and abnormal lipid metabolism group. The clinical data of the patients were collected and analyzed by SPSS software.
RESULTS
There were 454 patients with normal lipid metabolism and 163 patients with abnormal lipid metabolism. The SII level of the abnormal lipid metabolism group was higher than that of the normal group. As the SII quartile increased, TC, TG and LDL increased, while HDL decreased accordingly. The SII level was positively correlated with TC, TG and LDL, and negatively correlated with HDL (all P < 0.05). Among them, SII had the best predictive efficiency for dyslipidemia of polycyctic ovary syndrome at 489.375 (AUC: 0.718, 95%CI: 0.672-0.764), and SII was still associated with the increased occurrence of PCOS dyslipidemia after excluding confounding factors (P < 0.05).
CONCLUSION
The high level of SII has a correlation with the occurrence of dyslipidemia in PCOS patients, and it has a value in the early diagnosis of PCOS.
背景
多囊卵巢综合征（PCOS）是导致育龄期妇女不孕的主要因素之一，常伴有肥胖和慢性低度炎症等代谢变化。慢性炎症可能在代谢性疾病的发生和发展中起重要作用。因此，探讨 PCOS 患者脂代谢异常与炎症之间的关系具有重要意义。本研究旨在分析 PCOS 患者全身免疫炎症（SII）标志物与血脂异常的相关性及其在早期诊断中的价值。
方法
选取 2020 年 1 月至 2022 年 12 月在兰州大学第一医院生殖中心就诊的年龄 20-35 岁的 PCOS 患者 617 例（根据 Rotterdam 诊断标准）。根据血脂异常的有无，将患者分为血脂正常组和血脂异常组。收集并采用 SPSS 软件分析患者的临床资料。
结果
血脂正常组 454 例，血脂异常组 163 例。血脂异常组的 SII 水平高于正常组。随着 SII 四分位数的增加，TC、TG 和 LDL 升高，而 HDL 则相应降低。SII 水平与 TC、TG 和 LDL 呈正相关，与 HDL 呈负相关（均 P<0.05）。其中，SII 对多囊卵巢综合征血脂异常的预测效率最高，为 489.375（AUC：0.718，95%CI：0.672-0.764），排除混杂因素后，SII 仍与 PCOS 血脂异常的发生增加相关（P<0.05）。
结论
高水平的 SII 与 PCOS 患者血脂异常的发生相关，对 PCOS 的早期诊断具有一定价值。
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