Department of Gynecological Endocrinology, Hangzhou women's hospital, Hangzhou, China.
Medicine (Baltimore). 2022 Jul 22;101(29):e29678. doi: 10.1097/MD.0000000000029678.
Polycystic ovary syndrome (PCOS) is associated with low-grade chronic inflammation. This was a retrospective case-control study. In the present study, the risk coefficients of neutrophil to lymphocyte ratio (NLR), high-sensitive C-reactive protein (hs-CRP), and mean platelet volume (MPV) in obese patients with PCOS were determined. This study was designed to investigate NLR, hs-CRP, and MPV levels in 68 obese patients with PCOS and 44 nonobese patients with PCOS, and our study group was matched with 47 obese and 43 nonobese controls, respectively. PCOS group had higher MPV, NLR, insulin, glucose, and HOMA-IR rates than those of the controls. Subgroup analyses revealed that the obese PCOS group had higher NLR, hs-CRP, and MPV levels compared to those of controls. The obese PCOS group had higher NLR, hs-CRP, and MPV levels compared to those of the nonobese PCOS group. The odds ratios and 95% confidence intervals of those variables (NLR, hs-CRP, MPV) were found significant (P < .05). NLR, hs-CRP, and MPV variables were found statistically significant in the analysis of receiver operating characteristics. Our study demonstrated that NLR, hs-CRP, and MPV levels are increased in patients with obese PCOS.
多囊卵巢综合征（PCOS）与低度慢性炎症有关。这是一项回顾性病例对照研究。本研究旨在确定肥胖 PCOS 患者中性粒细胞与淋巴细胞比值（NLR）、高敏 C 反应蛋白（hs-CRP）和平均血小板体积（MPV）的风险系数。该研究共纳入 68 例肥胖 PCOS 患者和 44 例非肥胖 PCOS 患者，以及 47 例肥胖和 43 例非肥胖对照组。与对照组相比，PCOS 组的 MPV、NLR、胰岛素、血糖和 HOMA-IR 水平更高。亚组分析显示，与对照组相比，肥胖 PCOS 组的 NLR、hs-CRP 和 MPV 水平更高。与非肥胖 PCOS 组相比，肥胖 PCOS 组的 NLR、hs-CRP 和 MPV 水平更高。这些变量（NLR、hs-CRP、MPV）的比值比和 95%置信区间具有统计学意义（P<0.05）。在接受者操作特征分析中，NLR、hs-CRP 和 MPV 变量具有统计学意义。本研究表明，肥胖 PCOS 患者的 NLR、hs-CRP 和 MPV 水平升高。
