Luca Cezar, Boieriu Alexandra, Neculoiu Daniela, Tint Diana
Transilvania University, Brasov, Romania.
Cardiology Department, Cardiovascular Recovery Hospital, "Dr. Benedek Geza", Covasna, Romania.
Cardiol Res. 2024 Oct;15(5):369-376. doi: 10.14740/cr1702. Epub 2024 Oct 11.
This study aimed to investigate if remote ischemic preconditioning reduces the inflammatory process on patients undergoing coronary artery bypass grafting (CABG).
We conducted a case-control study involving 80 patients, half of whom underwent ischemic preconditioning for severe coronary artery disease (CAD) and subsequently underwent CABG. We assessed interleukin (IL)-1 and IL-6 levels using the enzyme-linked immunosorbent assay (ELISA) method, high-sensitivity troponin I (hsTnI) using chemiluminescent immunoassay (CLIA), and C-reactive protein (CRP) using the turbidimetric method at three key time points: before surgery (visit 1 or V1), immediately postoperatively (visit 2 or V2), and 1 week postoperatively (visit 3 or V3) in all subjects.
Ischemic preconditioned patients showed a significant decrease in proinflammatory markers (IL-1, IL-6) but not in CRP or hsTnI.
This study demonstrated that remote ischemic preconditioning significantly reduced the levels of specific proinflammatory markers (IL-1 and IL-6), which may suggest general systemic protection. However, it did not demonstrate cardioprotection , as evidenced by the absence of a statistically significant decrease in hsTnI level.
本研究旨在调查远程缺血预处理是否能减轻冠状动脉旁路移植术（CABG）患者的炎症反应。
我们进行了一项病例对照研究，纳入80例患者，其中一半因严重冠状动脉疾病（CAD）接受缺血预处理，随后接受CABG。在所有受试者的三个关键时间点：手术前（访视1或V1）、术后即刻（访视2或V2）和术后1周（访视3或V3），我们采用酶联免疫吸附测定（ELISA）法评估白细胞介素（IL）-1和IL-6水平，采用化学发光免疫测定（CLIA）法评估高敏肌钙蛋白I（hsTnI），采用比浊法评估C反应蛋白（CRP）。
缺血预处理患者的促炎标志物（IL-1、IL-6）显著降低，但CRP或hsTnI无明显变化。
本研究表明，远程缺血预处理显著降低了特定促炎标志物（IL-1和IL-6）的水平，这可能提示具有全身保护作用。然而，它并未显示出心脏保护作用，hsTnI水平未出现统计学显著下降即证明了这一点。
